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Complex societies precede moralizing gods throughout world history
Belief in moralizing gods followed the expansion of human societies and may have been preceded by doctrinal rituals that contributed to the initial rise of social complexity.
Harvey Whitehouse, Pieter François, Patrick E. Savage et al.
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Ratcheting up lipopolysaccharide transport
A protein complex that moves molecules called lipopolysaccharides between the two cell-wall membranes of certain bacteria is a target for antibiotics. Structures now reveal how this complex delivers its load irreversibly.
Russell E. Bishop
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Observation of unconventional chiral fermions with long Fermi arcs in CoSi
Angle-resolved photoemission spectroscopy measurements in CoSi reveal the presence of unconventional chiral fermions near the Fermi level, with giant surface Fermi arcs and one pair of well separated chiral nodes.
Zhicheng Rao, Hang Li, Tiantian Zhang et al.
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Structural basis of unidirectional export of lipopolysaccharide to the cell surface
Crystal structures of a five-protein complex comprising the inner-membrane components of the bacterial lipopolysaccharide transporter provide insight into the mechanism of extraction of lipopolysaccharide from the inner membrane and its transport to the outer membrane.
Tristan W. Owens, Rebecca J. Taylor, Karanbir S. Pahil et al.
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A potassium channel β-subunit couples mitochondrial electron transport to sleep
Sleep deprivation in Drosophila elevates reactive oxygen species in sleep-promoting neurons, leading to changes in potassium currents and spiking activity and thereby connecting energy metabolism, oxidative stress, and sleep.
Anissa Kempf, Seoho M. Song, Clifford B. Talbot et al.
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A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB
Non-canonical NF-κB is regulated by a negative feedback loop involving NIK-mediated activation of SIX1 and SIX2.
Zixu Liu, Katrina B. Mar, Natasha W. Hanners et al.
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Topological chiral crystals with helicoid-arc quantum states
Angle-resolved photoemission spectroscopy measurements reveal that CoSi and RhSi are nearly ideal topological conductors, with structural chirality and surface helicoid arcs of topological charge ±2 arising from bulk multifold chiral states.
Daniel S. Sanchez, Ilya Belopolski, Tyler A. Cochran et al.
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Structural basis of lipopolysaccharide extraction by the LptB2FGC complex
Cryo-electron microscopy structures of LptB2FGC, in nucleotide-free and vanadate-trapped states, reveal the mechanism of lipopolysaccharide extraction from the inner membrane of Gram-negative bacteria and a role for LptC in efficient lipopolysaccharide transport.
Yanyan Li,
Benjamin J. Orlando,
Maofu Liao
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Neoantigen-directed immune escape in lung cancer evolution
RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.
Rachel Rosenthal, Elizabeth Larose Cadieux, Roberto Salgado et al.
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Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase
In human neuroblastoma tumours, MYCN is engaged in a USP11–BRCA1-dependent manner to suppress the accumulation of stalled RNAPII and induces both the activation and repression of genes.
Steffi Herold, Jacqueline Kalb, Gabriele Büchel et al.
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The expanding landscape of ‘oncohistone’ mutations in human cancers
The characterization of missense histone mutations that occur across several cancer types provides insight into the potential role of these mutations in altering chromatin structure and potentially contributing to tumour development.
Benjamin A. Nacev, Lijuan Feng, John D. Bagert et al.
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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
Cryo-electron microscopy structures of tau filaments from the brains of three individuals with chronic traumatic encephalopathy reveal distinct assembled tau conformers, with a novel protofilament fold enclosing hydrophobic molecules.
Benjamin Falcon, Jasenko Zivanov, Wenjuan Zhang et al.
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The unexpected surface of asteroid (101955) Bennu
Observations of asteroid (101955) Bennu with NASA’s OSIRIS-REx spacecraft reveal an unexpected surficial diversity that poses a challenge to the success of the sample-return mission.
D. S. Lauretta, D. N. DellaGiustina, C. A. Bennett et al.
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Attosecond angular streaking and tunnelling time in atomic hydrogen
Simulation and measurement of the photoionization of atomic hydrogen at attosecond resolution confirm that the tunnelling of the ejected electron is instantaneous.
U. Satya Sainadh, Han Xu, Xiaoshan Wang et al.
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Visualizing DNA folding and RNA in embryos at single-cell resolution
Optical reconstruction of chromatin architecture and multiplex RNA labelling traces the DNA path in single cells and its relationship to transcription.
Leslie J. Mateo, Sedona E. Murphy, Antonina Hafner et al.
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Photonic topological insulator in synthetic dimensions
A spatially oscillating two-dimensional waveguide array is used to realize a photonic topological insulator in synthetic dimensions with modal-space edge states, unidirectionality and robust topological protection.
Eran Lustig, Steffen Weimann, Yonatan Plotnik et al.
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Diverse and robust molecular algorithms using reprogrammable DNA self-assembly
A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.
Damien Woods, David Doty, Cameron Myhrvold et al.
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Deep electrical imaging of the ultraslow-spreading Mohns Ridge
An inversion model for the ultraslow-spreading Mohns Ridge, combining controlled source electromagnetic and magnetotelluric data, reveals passive mantle upwelling controlled by slow and asymmetric plate movements.
Ståle Emil Johansen, Martin Panzner, Rune Mittet et al.
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Structural basis of STING binding with and phosphorylation by TBK1
The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires oligomerization of both proteins.
Conggang Zhang, Guijun Shang, Xiang Gui et al.
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