journal cover  
Nature Volume 567 Issue 7748
 
This Week  
 
 
Editorial  
 
 
 
It’s time to talk about ditching statistical significance
Spraying diseased citrus orchards with antibiotics could backfire
 
World View  
 
 
 
The World Bank must clean up its act
Vijaya Ramachandran
Research Highlights  
 
 
 
This issue's Research Highlights
Selections from the scientific literature.
Seven Days  
 
 
 
Impenetrable ice, Mars rumbles and nuclear-fusion lab
 
 


Application of CRISPR/Cas to the Generation of Genetically Engineered Mice

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News in Focus
 
News  
 
 
 
Thousands of scientists are backing the kids striking for climate change
Matthew Warren
Bull ‘super dads’ are being engineered to produce sperm from another father
Heidi Ledford
Scientists track damage from controversial deep-sea mining method
Olive Heffernan
English sea walls get wired to measure flood risk in real time
Alexandra Witze
Soap-bubble pioneer is first woman to win prestigious maths prize
Davide Castelvecchi
Features  
 
 
 
Protein-slaying drugs could be the next blockbuster therapies
Megan Scudellari
Antibiotics set to flood Florida’s troubled orange orchards
Maryn McKenna
 
 
Multimedia  
 
 
Nature Podcast 21 March 2019
This week, a plan to spray antibiotics onto orange trees, and is it time to retire statistical significance?
 
 
 
 
Comment
 
Comment  
 
 
 
Scientists rise up against statistical significance
Valentin Amrhein, Sander Greenland, Blake McShane
Books and Arts  
 
 
 
Evolving society: why humanity coheres
Agustín Fuentes
The rise and fall of scientific authority — and how to bring it back
Robert P. Crease
Correspondence  
 
 
 
Author lists: include original language script and unique identifiers
Zhongmin Wang
Manage forests as protection against warming
James E. M. Watson, Tom D. Evans, Oscar Venter et al.
Science looks worse because it’s getting better
Dashun Wang
Supercollider critics should learn from history
John Ellis
Three more unsung women – astatine discovery
Brett Thornton, Shawn Burdette
 
 
Careers
 
Columns  
 
 
 
Five ways media training helped me to boost the impact of my research
Caroline Kamau
 
 
Futures
 
A picture is worth
Beth Cato
 
 
Research
 
NEW ONLINE  
 
 
 
Complex societies precede moralizing gods throughout world history
Belief in moralizing gods followed the expansion of human societies and may have been preceded by doctrinal rituals that contributed to the initial rise of social complexity.
Harvey Whitehouse, Pieter François, Patrick E. Savage et al.
Ratcheting up lipopolysaccharide transport
A protein complex that moves molecules called lipopolysaccharides between the two cell-wall membranes of certain bacteria is a target for antibiotics. Structures now reveal how this complex delivers its load irreversibly.
Russell E. Bishop
Observation of unconventional chiral fermions with long Fermi arcs in CoSi
Angle-resolved photoemission spectroscopy measurements in CoSi reveal the presence of unconventional chiral fermions near the Fermi level, with giant surface Fermi arcs and one pair of well separated chiral nodes.
Zhicheng Rao, Hang Li, Tiantian Zhang et al.
Structural basis of unidirectional export of lipopolysaccharide to the cell surface
Crystal structures of a five-protein complex comprising the inner-membrane components of the bacterial lipopolysaccharide transporter provide insight into the mechanism of extraction of lipopolysaccharide from the inner membrane and its transport to the outer membrane.
Tristan W. Owens, Rebecca J. Taylor, Karanbir S. Pahil et al.
A potassium channel β-subunit couples mitochondrial electron transport to sleep
Sleep deprivation in Drosophila elevates reactive oxygen species in sleep-promoting neurons, leading to changes in potassium currents and spiking activity and thereby connecting energy metabolism, oxidative stress, and sleep.
Anissa Kempf, Seoho M. Song, Clifford B. Talbot et al.
A NIK–SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB
Non-canonical NF-κB is regulated by a negative feedback loop involving NIK-mediated activation of SIX1 and SIX2.
Zixu Liu, Katrina B. Mar, Natasha W. Hanners et al.
Topological chiral crystals with helicoid-arc quantum states
Angle-resolved photoemission spectroscopy measurements reveal that CoSi and RhSi are nearly ideal topological conductors, with structural chirality and surface helicoid arcs of topological charge ±2 arising from bulk multifold chiral states.
Daniel S. Sanchez, Ilya Belopolski, Tyler A. Cochran et al.
Structural basis of lipopolysaccharide extraction by the LptB2FGC complex
Cryo-electron microscopy structures of LptB2FGC, in nucleotide-free and vanadate-trapped states, reveal the mechanism of lipopolysaccharide extraction from the inner membrane of Gram-negative bacteria and a role for LptC in efficient lipopolysaccharide transport.
Yanyan Li, Benjamin J. Orlando, Maofu Liao
Neoantigen-directed immune escape in lung cancer evolution
RNA sequencing data and tumour pathology observations of non-small-cell lung cancers indicate that the immune cell microenvironment exerts strong evolutionary selection pressures that shape the immune-evasion capacity of tumours.
Rachel Rosenthal, Elizabeth Larose Cadieux, Roberto Salgado et al.
Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase
In human neuroblastoma tumours, MYCN is engaged in a USP11–BRCA1-dependent manner to suppress the accumulation of stalled RNAPII and induces both the activation and repression of genes.
Steffi Herold, Jacqueline Kalb, Gabriele Büchel et al.
The expanding landscape of ‘oncohistone’ mutations in human cancers
The characterization of missense histone mutations that occur across several cancer types provides insight into the potential role of these mutations in altering chromatin structure and potentially contributing to tumour development.
Benjamin A. Nacev, Lijuan Feng, John D. Bagert et al.
Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
Cryo-electron microscopy structures of tau filaments from the brains of three individuals with chronic traumatic encephalopathy reveal distinct assembled tau conformers, with a novel protofilament fold enclosing hydrophobic molecules.
Benjamin Falcon, Jasenko Zivanov, Wenjuan Zhang et al.
The unexpected surface of asteroid (101955) Bennu
Observations of asteroid (101955) Bennu with NASA’s OSIRIS-REx spacecraft reveal an unexpected surficial diversity that poses a challenge to the success of the sample-return mission.
D. S. Lauretta, D. N. DellaGiustina, C. A. Bennett et al.
Attosecond angular streaking and tunnelling time in atomic hydrogen
Simulation and measurement of the photoionization of atomic hydrogen at attosecond resolution confirm that the tunnelling of the ejected electron is instantaneous.
U. Satya Sainadh, Han Xu, Xiaoshan Wang et al.
Visualizing DNA folding and RNA in embryos at single-cell resolution
Optical reconstruction of chromatin architecture and multiplex RNA labelling traces the DNA path in single cells and its relationship to transcription.
Leslie J. Mateo, Sedona E. Murphy, Antonina Hafner et al.
 
News & Views  
 
 
 
Robotic collectives inspired by biological cells
Metin Sitti
Pore-forming small molecules offer a promising way to tackle cystic fibrosis
David N. Sheppard, Anthony P. Davis
Enzymes trapped and zapped for use outside cells
Alison Narayan
 
X-ray chimneys in the Galactic Centre
Masha Chernyakova
From the archive
The influence of a single neuron on its network
Ikuko T. Smith
Structures of STING protein illuminate this key regulator of inflammation
Andrea Ablasser
Perspectives  
 
 
 
Van der Waals integration before and beyond two-dimensional materials
Recent advances and future directions in the use of van der Waals integration beyond two-dimensional materials are reviewed.
Yuan Liu, Yu Huang, Xiangfeng Duan
Articles  
 
 
 
Single-neuron perturbations reveal feature-specific competition in V1
A combination of optogenetics and calcium imaging at the single-neuron level provides evidence for feature-specific competition among neurons in primary visual cortex.
Selmaan N. Chettih, Christopher D. Harvey
Gboxin is an oxidative phosphorylation inhibitor that targets glioblastoma
Gboxin and its chemical derivatives inhibit the growth of primary human and mouse glioblastoma cells, but not of mouse embryonic fibroblasts or neonatal astrocytes, by targeting mitochondrial oxidative phosphorylation complexes.
Yufeng Shi, S. Kyun Lim, Qiren Liang et al.
Letters  
 
 
 
An X-ray chimney extending hundreds of parsecs above and below the Galactic Centre
Huge X-ray structures, termed Galactic Centre ‘chimneys’, extending hundreds of parsecs above and below the Galactic plane, appear to be exhaust channels connecting the Galactic Centre region to the Fermi bubbles.
G. Ponti, F. Hofmann, E. Churazov et al.
Random anti-lasing through coherent perfect absorption in a disordered medium
Coherent perfect absorption in a disordered medium is demonstrated experimentally in the microwave regime through the realization of a random anti-laser that absorbs engineered radiation with near-perfect efficiency.
Kevin Pichler, Matthias Kühmayer, Julian Böhm et al.
Photonic topological insulator in synthetic dimensions
A spatially oscillating two-dimensional waveguide array is used to realize a photonic topological insulator in synthetic dimensions with modal-space edge states, unidirectionality and robust topological protection.
Eran Lustig, Steffen Weimann, Yonatan Plotnik et al.
Particle robotics based on statistical mechanics of loosely coupled components
A stochastic robotic system shows deterministic behaviour—such as locomotion, object transport and phototaxis—from the collective motion of many loosely coupled disk-shaped ‘particles’ that perform only volumetric oscillations.
Shuguang Li, Richa Batra, David Brown et al.
Diverse and robust molecular algorithms using reprogrammable DNA self-assembly
A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical systems.
Damien Woods, David Doty, Cameron Myhrvold et al.
Deacylative transformations of ketones via aromatization-promoted C–C bond activation
Aromatization-driven C–C bond activation through iridium/phosphine catalysis enables deacylative transformations in various ketone substrates.
Yan Xu, Xiaotian Qi, Pengfei Zheng et al.
Deep electrical imaging of the ultraslow-spreading Mohns Ridge
An inversion model for the ultraslow-spreading Mohns Ridge, combining controlled source electromagnetic and magnetotelluric data, reveals passive mantle upwelling controlled by slow and asymmetric plate movements.
Ståle Emil Johansen, Martin Panzner, Rune Mittet et al.
Feature-selective encoding of substrate vibrations in the forelimb somatosensory cortex
Responses to passive vibration of the forelimb in the mouse somatosensory cortex rely on a rate code that is selectively tuned to a combination of stimulus frequency and amplitude, and originate from deep mechanoreceptors close to the bones.
Mario Prsa, Karin Morandell, Géraldine Cuenu et al.
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
Cryo-electron microscopy structures of full-length STING show that cyclic GMP–AMP induces a half-turn rotation of the ligand-binding domain relative to the transmembrane domain, forming a tetramer and higher-order oligomers for signalling.
Guijun Shang, Conggang Zhang, Zhijian J. Chen et al.
Structural basis of STING binding with and phosphorylation by TBK1
The cryo-electron microscopy structure of human TBK1 in complex with cyclic GMP–AMP-bound chicken STING reveals a binding mode that suggests that STING phosphorylation by TBK1 requires oligomerization of both proteins.
Conggang Zhang, Guijun Shang, Xiang Gui et al.
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups
A statistical framework for breast-cancer recurrence uses long-term follow-up data and a knowledge of molecular subcategories to model distinct disease stages and to predict the risk of relapse.
Oscar M. Rueda, Stephen-John Sammut, Jose A. Seoane et al.
Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia
Amphotericin B forms nonselective transmembrane ion channels, and restores host defences of cystic fibrosis airway epithelia independently of the regulatory function of cystic fibrosis transmembrane conductance.
Katrina A. Muraglia, Rajeev S. Chorghade, Bo Ram Kim et al.
Mechanism of DNA translocation underlying chromatin remodelling by Snf2
Cryo-EM structures of yeast Snf2 bound to the nucleosome in the presence of ADP or an ATP analogue reveal that Snf2 binding leads to distortion of the DNA, and a two-step mechanism underlying chromatin remodelling by Snf2 is proposed.
Meijing Li, Xian Xia, Yuanyuan Tian et al.
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m6A modifications co-transcriptionally.
Huilin Huang, Hengyou Weng, Keren Zhou et al.
Discovery of a pathway for terminal-alkyne amino acid biosynthesis
Microbial generation of a terminal-alkyne-containing amino acid can be encoded into E. coli and provides the potential for in vivo generation of proteins and natural products for click chemistry.
J. A. Marchand, M. E. Neugebauer, M. C. Ing et al.
 
 
 
 
Amendments & Corrections
 
Author Correction: Hundred-fold enhancement in far-field radiative heat transfer over the blackbody limit
Dakotah Thompson, Linxiao Zhu, Rohith Mittapally et al.
Author Correction: Trade-offs in using European forests to meet climate objectives
Sebastiaan Luyssaert, Guillaume Marie, Aude Valade et al.
Publisher Correction: Damage-tolerant architected materials inspired by crystal microstructure
Minh-Son Pham, Chen Liu, Iain Todd et al.
 
 
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Nature Index Japan 2019
Spotlight   
 
 
 
Materials science in China
 
 
 
 
 

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