journal cover  
Nature Volume 564 Issue 7734
 
This Week  
 
 
Editorial  
 
 
 
How to respond to CRISPR babies
The secrets of Lonesome George
Rules for a safe climate
 
 
World View  
 
 
 
How sure are you of your result? Put a number on it
Steven N. Goodman
Research Highlights  
 
 
 
This issue's Research Highlights
Selections from the scientific literature.
Seven Days  
 
 
 
Black-hole bounty, Ebola emergency and UK science minister resigns
 
 
 
 
News in Focus
 
News  
 
 
 
CRISPR-baby scientist fails to satisfy critics
David Cyranoski
China set to launch first-ever spacecraft to the far side of the Moon
Andrew Silver
Venice anti-flood gates could wreck lagoon ecosystem
Lou Del Bello
Tehran’s drastic sinking exposed by satellite data
Kate Ravilious
Geologists are measuring bullet damage to ancient Middle Eastern settlements
Sarah Wild
Features  
 
 
 
These dusty young stars are changing the rules of planet-building
Rebecca Boyle
The silent epidemic killing more people than HIV, malaria or TB
Ian Graber-Stiehl
 
 
Multimedia  
 
 
Nature Podcast 06 December 2018
This week, improving heart xenotransplants, and soil bacteria versus phages.
 
 
Nature Outline: Ulcerative Colitis

Ulcerative colitis is a debilitating and incurable condition. But researchers have found fresh angles of attack, and a host of upcoming treatments raise the prospect of a durable victory against this common form of inflammatory bowel disease.

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TRI
 
 
Comment
 
Comment  
 
 
 
Emissions are still rising: ramp up the cuts
Christiana Figueres, Corinne Le Quéré, Anand Mahindra et al.
Global warming will happen faster than we think
Yangyang Xu, Veerabhadran Ramanathan, David G. Victor
Put more carbon in soils to meet Paris climate pledges
Cornelia Rumpel, Farshad Amiraslani, Lydie-Stella Koutika et al.
Books and Arts  
 
 
 
Do luxe labs shape science?
Kendall Powell
Big oil in the dock, the influenza trail, and insects as icons: Books in brief
Barbara Kiser
Correspondence  
 
 
 
Plan S will hit some academic societies hard
Michael Jennions, Rob Lanfear, Shinichi Nakagawa
Boost university voices at COP24 UN climate meeting
Samantha Basile, Michael Lerner, Keyon Rostamnezhad
Brazil’s new government threatens food security and biodiversity
Marina Demaria Venâncio, Kamila Pope, Stefan Sieber
Road charges in real time are not a silver bullet
Geertje Schuitema, Linda Steg
Helmholtz mentored many Nobelists
Sameen Ahmed Khan
 
 
Technology
 
Technology Feature  
 
 
 
Transparent tissues bring cells into focus for microscopy
Michael Eisenstein
 
 
Careers
 
Features  
 
 
 
Meet the supervisors who helped to shape four scientists’ careers
Emily Sohn
 
 
Futures
 
A beginner’s guide to space travel and seafood
Steven Fischer
 
 
Research
 
NEW ONLINE  
 
 
 
Consistent success in life-supporting porcine cardiac xenotransplantation
α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.
Matthias Längin, Tanja Mayr, Bruno Reichart et al.
Single-cell mapping of lineage and identity in direct reprogramming
Combinatorial tagging of single cells using expressed DNA barcodes, delivered by a lentiviral vector, is used to track individual cells and reconstruct their lineages and trajectories during cell fate reprogramming.
Brent A. Biddy, Wenjun Kong, Kenji Kamimoto et al.
Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks
A deficiency of Dna2 causes duplication of DNA fragments and their insertion into the genome at double-stranded breaks in yeast.
Yang Yu, Nhung Pham, Bo Xia et al.
Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur
The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.
Johan Lindgren, Peter Sjövall, Volker Thiel et al.
Inner ear development in cyclostomes and evolution of the vertebrate semicircular canals
The differentiation of the inner ear in the lamprey Lethenteron camtschaticum and hagfish Eptatretus burgeri sheds light on the evolution of the semicircular canals of jawed vertebrates.
Shinnosuke Higuchi, Fumiaki Sugahara, Juan Pascual-Anaya et al.
Bacterial defence molecules target viral DNA
Bacteria can use specific protein-based strategies to defend individual cells against viruses. Evidence that bacterial small molecules also target viruses provides fresh insights into how bacteria thwart viral infection.
Martha R. J. Clokie
Controlling orthogonal ribosome subunit interactions enables evolution of new function
Orthogonal ribosomes are engineered in which the two subunits are stapled together in a way that limits association with endogenous subunits in cells, enabling the evolution of new functionality in the orthogonal ribosome.
Wolfgang H. Schmied, Zakir Tnimov, Chayasith Uttamapinant et al.
Capture of nebular gases during Earth’s accretion is preserved in deep-mantle neon
The distinctive 20Ne/22Ne ratio in material thought to come from deep mantle plumes provides evidence for nebular gas as a source of volatiles in Earth’s interior.
Curtis D. Williams, Sujoy Mukhopadhyay
Success for pig-to-baboon heart transplants
A modified protocol has enabled baboons that received transplanted pig hearts to survive for more than six months. This improvement on previous efforts brings pig-to-human heart transplants a step closer.
Christoph Knosalla
Complex mammalian-like haematopoietic system found in a colonial chordate
The identification of a complex haematopoietic system in a colonial tunicate sheds light on the evolution of the mammalian blood system.
Benyamin Rosental, Mark Kowarsky, Jun Seita et al.
A chemical defence against phage infection
Streptomyces secondary metabolites provide a chemical defence against phage predation.
Sarah Kronheim, Martin Daniel-Ivad, Zhuang Duan et al.
A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.
Felix Leroy, Jung Park, Arun Asok et al.
From the archive
How Nature reported innovative moving walkways in 1968, and a plea to ban gases as weapons in 1918.
Scalable energy-efficient magnetoelectric spin–orbit logic
A scalable spintronic device operating via spin–orbit transduction and magnetoelectric switching and using advanced quantum materials shows non-volatility and improved performance and energy efficiency compared with CMOS devices.
Sasikanth Manipatruni, Dmitri E. Nikonov, Chia-Ching Lin et al.
Chemical differentiation, cold storage and remobilization of magma in the Earth’s crust
Magma storage and differentiation in the Earth’s crust mainly occurs by reactive melt flow in long-lived mush reservoirs, rather than by fractional crystallization in magma chambers, as previously thought.
M. D. Jackson, J. Blundy, R. S. J. Sparks
 
News & Views  
 
 
 
The rocky road to biomolecules
John A. Baross
Elusive spin textures discovered
Seonghoon Woo
Exit route evolved into entry path in plants
Danny J. Schnell
 


Cellular Metabolism

This conference will discuss fundamental questions such as how cells sense their metabolic status, how cells regulate their metabolism and how cellular metabolism, in turn, controls signaling and cellular function in different physiological contexts.

April 8-11, 2019 | Xiamen, China

REGISTER NOW >>
Long-sought decay of the Higgs boson seen
Boris Tuchming
Reduced oxygen consumption by fat cells improves metabolic defects
Nolwenn Joffin, Philipp E. Scherer
Satellite pinpoints ammonia sources globally
Mark A. Sutton, Clare M. Howard
Location matters for insulin-producing cells
Francesca M. Spagnoli
Brief Communications Arising  
 
 
 
Stiff competition
G. W. Milton
Berger et al. reply
J. B. Berger, H. N. G. Wadley, R. M. McMeeking
Articles  
 
 
 
Change in future climate due to Antarctic meltwater
Accounting for meltwater from the Antarctic Ice Sheet in simulations of global climate leads to substantial changes in future climate projections and identifies a potential feedback mechanism that exacerbates melting.
Ben Bronselaer, Michael Winton, Stephen M. Griffies et al.
Abiotic synthesis of amino acids in the recesses of the oceanic lithosphere
High-resolution imaging techniques show that aromatic amino acids such as tryptophan formed abiotically and were subsequently preserved at depth beneath the Atlantis Massif of the Mid-Atlantic Ridge, supporting the hydrothermal theory for the origin of life.
Bénédicte Ménez, Céline Pisapia, Muriel Andreani et al.
Amphioxus functional genomics and the origins of vertebrate gene regulation
Genomic, epigenomic and transcriptomic data derived from the Mediterranean amphioxus (Branchiostoma lanceolatum) provide insights into the evolution of the genomic regulatory landscape of chordates.
Ferdinand Marlétaz, Panos N. Firbas, Ignacio Maeso et al.
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
Recruitment of NLRP3 to the dispersed trans-Golgi network via binding to PtdIns4P is required for activation of the NLRP3 inflammasome by diverse stimuli.
Jueqi Chen, Zhijian J. Chen
Type 9 secretion system structures reveal a new protein transport mechanism
Cryo-electron microscopy structures of the protein-conducting translocon of the type 9 secretion system reveal its architecture and mechanism of translocation.
Frédéric Lauber, Justin C. Deme, Susan M. Lea et al.
Letters  
 
 
 
An experiment to search for dark-matter interactions using sodium iodide detectors
Early results from the COSINE-100 experiment—designed to test a much-debated claim of the detection of a dark-matter signal—show no indications of dark matter, providing evidence against the previous claim.
The COSINE-100 Collaboration
Atomic clock performance enabling geodesy below the centimetre level
Improved techniques allow the measurement of a frequency difference with an uncertainty of the order of 10–19 between two independent atomic optical lattice clocks, suggesting that they may be able to improve state-of-the-art geodetic techniques.
W. F. McGrew, X. Zhang, R. J. Fasano et al.
Extreme-ultraviolet refractive optics
A refractive lens and a refractive prism for extreme-ultraviolet radiation have been developed that use the deflection of the radiation in an inhomogeneous jet of atoms.
L. Drescher, O. Kornilov, T. Witting et al.
Transformation between meron and skyrmion topological spin textures in a chiral magnet
A magnetically induced two-dimensional square lattice of merons and antimerons is observed in real space, along with its transformation into a hexagonal lattice of skyrmions at room temperature.
X. Z. Yu, W. Koshibae, Y. Tokunaga et al.
Industrial and agricultural ammonia point sources exposed
Satellite observations reveal over 200 ammonia hotspots associated with agricultural and industrial point sources, which emit much larger quantities of ammonia to the atmosphere than previously thought.
Martin Van Damme, Lieven Clarisse, Simon Whitburn et al.
Nonlinear rise in Greenland runoff in response to post-industrial Arctic warming
Ice-core-derived melt records reveal that atmospheric warming has recently intensified Greenland ice-sheet surface melt and runoff to levels that are exceptional over at least the last 350 years.
Luke D. Trusel, Sarah B. Das, Matthew B. Osman et al.
The hippocampus is crucial for forming non-hippocampal long-term memory during sleep
Hippocampal activity during a period of sleep after memory encoding is crucial for forming long-term memories in rats, even for types of memory considered not to be hippocampus-dependent.
Anuck Sawangjit, Carlos N. Oyanedel, Niels Niethard et al.
Mechanosignalling via integrins directs fate decisions of pancreatic progenitors
Single-cell analysis reveals that interactions with the extracellular matrix via integrin α5 and mechanotransducer YAP1 determine whether pancreatic progenitors develop along the duct or endocrine lineages.
Anant Mamidi, Christy Prawiro, Philip A. Seymour et al.
VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche
In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.
Dantong Li, Wenzhi Xue, Mei Li et al.
TIC236 links the outer and inner membrane translocons of the chloroplast
TIC236 is an inner-membrane protein that binds to the outer-membrane channel TOC75 to create a long, stable bridge that enables the transport of proteins into chloroplasts.
Yih-Lin Chen, Lih-Jen Chen, Chiung-Chih Chu et al.
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells
PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.
Xiangbo Meng, Xiwei Liu, Xingdong Guo et al.
Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1
Stella, a factor essential for female fertility, protects the oocyte methylome in mice by suppressing de novo DNA methylation mediated by the DNA methyltransferase DNMT1.
Yingfeng Li, Zhuqiang Zhang, Jiayu Chen et al.
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
The kinase CDK12 suppresses usage of intronic polyadenylation sites and thereby promotes the expression of genes involved in homologous recombination DNA repair.
Sara J. Dubbury, Paul L. Boutz, Phillip A. Sharp
 
 
Amendments & Corrections
 
Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
Roshni Roy Chowdhury, Francesco Vallania, Qianting Yang et al.
Author Correction: Cryo-EM of the dynamin polymer assembled on lipid membrane
Leopold Kong, Kem A. Sochacki, Huaibin Wang et al.
Publisher Correction: Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease
Sandro Da Mesquita, Antoine Louveau, Andrea Vaccari et al.
Publisher Correction: Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys
Erica N. Borducchi, Jinyan Liu, Joseph P. Nkolola et al.
 
 
Spotlight
 
Spotlight  
 
 
 
Cell biology
 
 
 
 
 

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