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Consistent success in life-supporting porcine cardiac xenotransplantation
α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.
Matthias Längin, Tanja Mayr, Bruno Reichart et al.
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Single-cell mapping of lineage and identity in direct reprogramming
Combinatorial tagging of single cells using expressed DNA barcodes, delivered by a lentiviral vector, is used to track individual cells and reconstruct their lineages and trajectories during cell fate reprogramming.
Brent A. Biddy, Wenjun Kong, Kenji Kamimoto et al.
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Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks
A deficiency of Dna2 causes duplication of DNA fragments and their insertion into the genome at double-stranded breaks in yeast.
Yang Yu, Nhung Pham, Bo Xia et al.
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Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur
The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.
Johan Lindgren, Peter Sjövall, Volker Thiel et al.
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Inner ear development in cyclostomes and evolution of the vertebrate semicircular canals
The differentiation of the inner ear in the lamprey Lethenteron camtschaticum and hagfish Eptatretus burgeri sheds light on the evolution of the semicircular canals of jawed vertebrates.
Shinnosuke Higuchi, Fumiaki Sugahara, Juan Pascual-Anaya et al.
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Bacterial defence molecules target viral DNA
Bacteria can use specific protein-based strategies to defend individual cells against viruses. Evidence that bacterial small molecules also target viruses provides fresh insights into how bacteria thwart viral infection.
Martha R. J. Clokie
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Controlling orthogonal ribosome subunit interactions enables evolution of new function
Orthogonal ribosomes are engineered in which the two subunits are stapled together in a way that limits association with endogenous subunits in cells, enabling the evolution of new functionality in the orthogonal ribosome.
Wolfgang H. Schmied, Zakir Tnimov, Chayasith Uttamapinant et al.
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Capture of nebular gases during Earth’s accretion is preserved in deep-mantle neon
The distinctive 20Ne/22Ne ratio in material thought to come from deep mantle plumes provides evidence for nebular gas as a source of volatiles in Earth’s interior.
Curtis D. Williams,
Sujoy Mukhopadhyay
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Success for pig-to-baboon heart transplants
A modified protocol has enabled baboons that received transplanted pig hearts to survive for more than six months. This improvement on previous efforts brings pig-to-human heart transplants a step closer.
Christoph Knosalla
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Complex mammalian-like haematopoietic system found in a colonial chordate
The identification of a complex haematopoietic system in a colonial tunicate sheds light on the evolution of the mammalian blood system.
Benyamin Rosental, Mark Kowarsky, Jun Seita et al.
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A chemical defence against phage infection
Streptomyces secondary metabolites provide a chemical defence against phage predation.
Sarah Kronheim, Martin Daniel-Ivad, Zhuang Duan et al.
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A circuit from hippocampal CA2 to lateral septum disinhibits social aggression
Pyramidal neurons in the hippocampal CA2 region in mice promote social aggression via a disinhibitory circuit involving the lateral septum and ventromedial hypothalamus.
Felix Leroy, Jung Park, Arun Asok et al.
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From the archive
How Nature reported innovative moving walkways in 1968, and a plea to ban gases as weapons in 1918.
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Scalable energy-efficient magnetoelectric spin–orbit logic
A scalable spintronic device operating via spin–orbit transduction and magnetoelectric switching and using advanced quantum materials shows non-volatility and improved performance and energy efficiency compared with CMOS devices.
Sasikanth Manipatruni, Dmitri E. Nikonov, Chia-Ching Lin et al.
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Chemical differentiation, cold storage and remobilization of magma in the Earth’s crust
Magma storage and differentiation in the Earth’s crust mainly occurs by reactive melt flow in long-lived mush reservoirs, rather than by fractional crystallization in magma chambers, as previously thought.
M. D. Jackson,
J. Blundy,
R. S. J. Sparks
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Cellular Metabolism
This conference will discuss fundamental questions such as how cells sense their metabolic status, how cells regulate their metabolism and how cellular metabolism, in turn, controls signaling and cellular function in different physiological contexts.
April 8-11, 2019 | Xiamen, China
REGISTER NOW >> |
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Brief Communications Arising
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Change in future climate due to Antarctic meltwater
Accounting for meltwater from the Antarctic Ice Sheet in simulations of global climate leads to substantial changes in future climate projections and identifies a potential feedback mechanism that exacerbates melting.
Ben Bronselaer, Michael Winton, Stephen M. Griffies et al.
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Abiotic synthesis of amino acids in the recesses of the oceanic lithosphere
High-resolution imaging techniques show that aromatic amino acids such as tryptophan formed abiotically and were subsequently preserved at depth beneath the Atlantis Massif of the Mid-Atlantic Ridge, supporting the hydrothermal theory for the origin of life.
Bénédicte Ménez, Céline Pisapia, Muriel Andreani et al.
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Atomic clock performance enabling geodesy below the centimetre level
Improved techniques allow the measurement of a frequency difference with an uncertainty of the order of 10–19 between two independent atomic optical lattice clocks, suggesting that they may be able to improve state-of-the-art geodetic techniques.
W. F. McGrew, X. Zhang, R. J. Fasano et al.
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Extreme-ultraviolet refractive optics
A refractive lens and a refractive prism for extreme-ultraviolet radiation have been developed that use the deflection of the radiation in an inhomogeneous jet of atoms.
L. Drescher, O. Kornilov, T. Witting et al.
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Industrial and agricultural ammonia point sources exposed
Satellite observations reveal over 200 ammonia hotspots associated with agricultural and industrial point sources, which emit much larger quantities of ammonia to the atmosphere than previously thought.
Martin Van Damme, Lieven Clarisse, Simon Whitburn et al.
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VCAM-1+ macrophages guide the homing of HSPCs to a vascular niche
In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.
Dantong Li, Wenzhi Xue, Mei Li et al.
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