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Thermal stress induces glycolytic beige fat formation via a myogenic state
The mouse develops a developmentally and functionally distinct, non-canonical beige fat cell type as an adaptation to cold ambient temperature.
Yong Chen, Kenji Ikeda, Takeshi Yoneshiro et al.
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The global distribution and trajectory of tidal flats
Analyses of over 700,000 satellite images to map the global extent of tidal flats over the past thirty years, and enable assessments of the status and likely future trajectories of these coastal ecosystems.
Nicholas J. Murray, Stuart R. Phinn, Michael DeWitt et al.
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Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
Neoantigen-targeting vaccines are a feasible therapy for tumours with a low mutation burden and immunologically ‘cold’ tumour microenvironment, as neoantigen-specific T cells from the peripheral blood migrate into intracranial glioblastoma, thereby altering the immune milieu of the glioblastoma.
Derin B. Keskin, Annabelle J. Anandappa, Jing Sun et al.
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Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
Evolved iron-containing enzymes based on cytochrome P450 achieve selective intermolecular alkylation of sp3 C–H bonds through a carbene C–H insertion strategy.
Ruijie K. Zhang, Kai Chen, Xiongyi Huang et al.
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Programmable design of orthogonal protein heterodimers
Computational design incorporating modular buried hydrogen networks produces highly orthogonal protein heterodimers.
Zibo Chen, Scott E. Boyken, Mengxuan Jia et al.
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Fat cells with a sweet tooth
Some fat cells convert energy into heat, so targeting them to induce weight loss is appealing. The discovery that a subset of the cells burns glucose, rather than both glucose and lipids, could improve our ability to do just that.
Wenfei Sun,
Christian Wolfrum
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Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity
Phenotypically, transcriptionally and metabolically diverse subsets of TH17 cells develop in a chronic autoimmune disease: one subset has inferred stemness features and low anabolic metabolism, while a reciprocal subset has higher metabolic activity that supports transdifferentiation into TH1 cells.
Peer W. F. Karmaus, Xiang Chen, Seon Ah Lim et al.
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Actively personalized vaccination trial for newly diagnosed glioblastoma
In a phase I trial, highly individualized peptide vaccines against unmutated tumour antigens and neoepitopes elicited sustained responses in CD8+ and CD4+ T cells, respectively, in patients with newly diagnosed glioblastoma.
Norbert Hilf, Sabrina Kuttruff-Coqui, Katrin Frenzel et al.
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Immune cells track hard-to-target brain tumours
Clinical trials reveal that personalized vaccines can boost immune-cell responses to brain tumours that don’t usually respond to immunotherapy. The findings also point to how to improve such treatments.
Neeha Zaidi,
Elizabeth M. Jaffee
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From the archive
How Nature reported a strange apparition in 1918, and the latest Christmas toys in 1968.
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Quantum Hall effect based on Weyl orbits in Cd3As2
Quantized conductivity is observed along a Weyl orbit in wedge-shaped samples of the topological semimetal Cd3As2, providing evidence of the quantum Hall effect in three dimensions.
Cheng Zhang, Yi Zhang, Xiang Yuan et al.
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Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Deletion of the A-to-I double-stranded RNA-editing enzyme ADAR1 sensitizes tumour cells to immunotherapy.
Jeffrey J. Ishizuka, Robert T. Manguso, Collins K. Cheruiyot et al.
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Observation of the nonlinear Hall effect under time-reversal-symmetric conditions
The nonlinear Hall effect is observed in bilayer WTe2 in the absence of a magnetic field, providing a direct measure of the dipole moment of the Berry curvature.
Qiong Ma, Su-Yang Xu, Huitao Shen et al.
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Medals and awards 2019 nominations now open
Royal Society medals and awards recognise excellence in science and technology and celebrate outstanding scientific achievement. We invite you to nominate excellent candidates from across the disciplines.
The closing date for nominations is Monday 28 January 2019, 3pm.
Details of all awards and nominate online |
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Brief Communications Arising
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Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur
The presence of blubber and distribution of melanophores in a countershading pattern in an Early Jurassic ichthyosaur demonstrate that the evolutionary convergence of these reptiles with extant marine amniotes extends to the cellular and molecular levels.
Johan Lindgren, Peter Sjövall, Volker Thiel et al.
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Measurement of the Casimir torque
The theoretically predicted Casimir torque, which causes charge-neutral, birefringent materials to rotate towards a preferred alignment, is measured.
David A. T. Somers, Joseph L. Garrett, Kevin J. Palm et al.
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Origin of spatial variation in US East Coast sea-level trends during 1900–2017
Vertical motions of Earth’s crust had the greatest effect on regional spatial differences in relative sea-level trends along the eastern coast of the USA during 1900–2017, explaining most of the large-scale spatial variance in regional rates of sea-level rise.
Christopher G. Piecuch, Peter Huybers, Carling C. Hay et al.
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Consistent success in life-supporting porcine cardiac xenotransplantation
α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and human thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons.
Matthias Längin, Tanja Mayr, Bruno Reichart et al.
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