In this week's issue of Science

SPECIAL SECTION:
BREAKTHROUGH OF THE YEAR
 

WINNER:
Development cell by cell
 

RUNNERS-UP:
Ice age impact
 

An archaic human 'hybrid'
 

How cells marshal their contents
 

Forensic genealogy comes of age
 

Molecular windows into primeval worlds
 

Gene-silencing drug approved
 

Molecular structures made simple
 

Messengers from a far-off galaxy
 

#MeToo makes a difference
 

BREAKDOWNS OF THE YEAR
Climate-fueled disasters rise, political action stalls
 

IN BRIEF
News at a glance
 

IN DEPTH
Hints of young planets puzzle theorists
D. Clery
 

Universities 'held hostage' in Nicaragua's political crisis
L. Wade
 

Antarctic ice melt 125,000 years ago offers warning
P. Voosen
 

Fossils push back origin of key plant groups millions of years
E. Pennisi
 

Link to Alzheimer's seen in nodding syndrome
L. Spinney
 

'Five Deeps' mission to explore mysterious ocean trenches
E. Stokstad
 

National Academies urges renewed commitment to fusion
A. Cho
 

PERSPECTIVES
Tessellating tiny tetrahedrons
S. Wu and Y. Sun
 

Chemotherapy and tumor immunity
S. Cornen and E. Vivier
 

Seeing a global web of connected systems
M. Scheffer and E. H. van Nes
 

Hydropatterning—how roots test the waters
R. F. H. Giehl and N. von Wirén
 

Unusual transcription factor protects against heart failure
A. Padmanabhan and S. M. Haldar
 

Escaping atmospheres of extrasolar planets
M. Brogi
 

POLICY FORUM
Next-generation wargames
Andrew W. Reddie et al.
 

BOOKS ET AL.
The sex robots are here
L. Frank
 

Beyond blood
S. Zadeh
 

RESEARCH ARTICLES
E-C coupling structural protein junctophilin-2 encodes a stress-adaptive transcription regulator
A. Guo et al.
 

Structure of human TFIID and mechanism of TBP loading onto promoter DNA
A. B. Patel et al.
 

Structures and gating mechanism of human TRPM2
L. Wang et al.
 

A linear cobalt(II) complex with maximal orbital angular momentum from a non-Aufbau ground state
P. C. Bunting et al.
 

Cascading regime shifts within and across scales
J. C. Rocha et al.
 

REPORTS
Spectrally resolved helium absorption from the extended atmosphere of a warm Neptune-mass exoplanet
R. Allart et al.
 

Ground-based detection of an extended helium atmosphere in the Saturn-mass exoplanet WASP-69b
L. Nortmann et al.
 

Electron-scale dynamics of the diffusion region during symmetric magnetic reconnection in space
R. B. Torbert et al.
 

Single-component quasicrystalline nanocrystal superlattices through flexible polygon tiling rule
Y. Nagaoka et al.
 

Magnetic hysteresis up to 80 kelvin in a dysprosium metallocene single-molecule magnet
F.-S. Guo et al.
 

Elevated trawling inside protected areas undermines conservation outcomes in a global fishing hot spot
M. Dureuil et al.
 

Root branching toward water involves posttranslational modification of transcription factor ARF7
B. Orosa-Puente et al.
 

The strength of long-range ties in population-scale social networks
P. S. Park et al.
 

A hidden cradle of plant evolution in Permian tropical lowlands
P. Blomenkemper et al.
 

NK cell—mediated cytotoxicity contributes to tumor control by a cytostatic drug combination
M. Ruscetti et al.
 

ATP-dependent force generation and membrane scission by ESCRT-III and Vps4
J. Schöneberg et al.
 

DEPARTMENTS
Editorial: Exploring organisms cell by cell
Jeremy Berg
 

Working Life: Forced to change—for good
Katarina Radošević
 

AAAS News & Notes
 

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