| |
Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control
Ubiquitin chains linked to cytoplasmic misfolded proteins are different from those linked to nuclear misfolded proteins, each requiring a distinct combination of molecular chaperones and ubiquitination circuitries.
Rahul S. Samant, Christine M. Livingston, Emily M. Sontag et al.
|
Emergence of multi-body interactions in a fermionic lattice clock
Clock spectroscopy of ultracold strontium atoms in a three-dimensional optical lattice is used to observe the onset of multi-body interactions that result from the underlying pairwise interactions between atoms.
A. Goban, R. B. Hutson, G. E. Marti et al.
|
Cellular stretch reveals superelastic powers
External forces can make cells undergo large, irreversible deformations. It emerges that stretched mammalian cells grown in vitro can enter a state called superelasticity, in which large, reversible deformations occur.
Manuel Théry,
Atef Asnacios
|
Deconstructive diversification of cyclic amines
Jose B. Roque, Yusuke Kuroda, Lucas T. Göttemann et al.
|
Active superelasticity in three-dimensional epithelia of controlled shape
Theoretical modelling in combination with measurements of tension and shape in epithelial domes of controlled geometry reveals a plateau of tension in tissue that is maintained by heterogeneous strain across cells.
Ernest Latorre, Sohan Kale, Laura Casares et al.
|
Three-dimensional collective charge excitations in electron-doped copper oxide superconductors
Resonant inelastic X-ray scattering on electron-doped copper oxide superconductors reveals a three-dimensional charge collective mode, which has properties suggestive of the long-sought acoustic plasmon.
M. Hepting, L. Chaix, E. W. Huang et al.
|
Resting zone of the growth plate houses a unique class of skeletal stem cells
In a mouse model, PTHrP-positive chondrocytes in the resting zone of the growth plate constitute a unique stem-cell population, which is initially unipotent and makes columnar chondrocytes that later exhibit multipotency.
Koji Mizuhashi, Wanida Ono, Yuki Matsushita et al.
|
The SWI/SNF complex is a mechanoregulated inhibitor of YAP and TAZ
The ARID1A-containing SWI/SNF complex operates as an inhibitor of the pro-oncogenic transcriptional coactivators YAP and TAZ; this interaction is regulated by cellular mechanotransduction.
Lei Chang, Luca Azzolin, Daniele Di Biagio et al.
|
A new road to cancer-drug resistance
The discovery of a mechanism that leads to cancer-therapy resistance highlights the many ways that tumour cells can adapt to survive — and reveals the limitations of categorizing patients by their gene mutations.
Katharina Schlacher
|
Dinosaur egg colour had a single evolutionary origin
A phylogenetic assessment based on Raman microspectroscopy of pigment traces in fossilized eggshells from all major dinosaur clades reveals that eggshell coloration and pigment pattern originated in nonavian theropod dinosaurs.
Jasmina Wiemann,
Tzu-Ruei Yang,
Mark A. Norell
|
TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle
Cytoplasmic, amyloid-like oligomeric assemblies that contain TDP-43 are increased in damaged tissues with elevated regeneration, thereby enhancing the possibility of amyloid fibre formation and/or aggregation of TDP-43 in disease.
Thomas O. Vogler, Joshua R. Wheeler, Eric D. Nguyen et al.
|
Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens
A subclass of ribonucleotide reductase in Mycoplasma pathogens contains a stable radical formed from a modified tyrosine residue, overturning the presumed requirement for a dinuclear metal site in aerobic ribonucleotide reductase.
Vivek Srinivas, Hugo Lebrette, Daniel Lundin et al.
|
Conformational transitions of the serotonin 5-HT3 receptor
Cryo-electron microscopy of the serotonin 5-HT3 receptor in complex with various ligands yields four distinct structures, capturing serotonin binding in detail and increasing understanding of the gating mechanism of the receptor.
Lucie Polovinkin, Ghérici Hassaine, Jonathan Perot et al.
|
Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3A receptor
Cryo-electron microscopy structures of the serotonin-bound 5-HT3A serotonin receptor show the receptor populating two distinct states, characterized by twisting in the extracellular and transmembrane domains relative to the apo state, which creates pathways for ion permeation.
Sandip Basak, Yvonne Gicheru, Shanlin Rao et al.
|
The metabolite dimethylsulfoxonium propionate extends the marine organosulfur cycle
A structurally unusual zwitterionic metabolite, dimethylsulfoxonium propionate (DMSOP), is synthesized by several dimethylsulfoniopropionate-producing microalgae and marine bacteria and is readily metabolized into dimethylsulfoxide by marine bacteria, expanding our knowledge of the marine organosulfur cycle.
Kathleen Thume, Björn Gebser, Liang Chen et al.
|
A neurodegenerative-disease protein forms beneficial aggregates in healthy muscle
Protein aggregation is a characteristic of several neurodegenerative diseases. But disease-associated aggregates of the protein TDP-43 have now been shown to have a beneficial role in healthy muscle.
Lindsay A. Becker,
Aaron D. Gitler
|
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells
DYNLL1 antagonizes end resection of DNA double-strand breaks, thereby inhibiting homologous repair, and the loss of DYNLL1 correlates with poor progression-free survival of patients with BRCA1-mutant ovarian cancer.
Yizhou Joseph He, Khyati Meghani, Marie-Christine Caron et al.
|
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Neuronal stimulation induces protein translation of m6A-methylated neuronal mRNAs facilitated by YTHDF1, and this process contributes to learning and memory.
Hailing Shi, Xuliang Zhang, Yi-Lan Weng et al.
|
From the archive
What Nature was saying 50 and 100 years ago.
|
Definitions for adult stem cells debated
Adult tissues must maintain themselves and regenerate after damage. But are these crucial functions mediated by dedicated populations of stem cells, or do differentiated cells adopt stem-cell-like properties according to an organ’s needs? Here, two scientists present evidence from both sides of the debate.
Pura Muñoz-Cánoves,
Meritxell Huch
|
Vowel recognition with four coupled spin-torque nano-oscillators
A network of four spin-torque nano-oscillators can be trained in real time to recognize spoken vowels, in a simple and scalable approach that could be exploited for large-scale neural networks.
Miguel Romera, Philippe Talatchian, Sumito Tsunegi et al.
|
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
Lei Zhang, Xin Yu, Liangtao Zheng et al.
|
|
|
|
|
|
 Scientific ReportsOpen for submissions Soft sensors and actuators
Guest editor: Il-Kwon Oh, KAIST, South Korea
This Collection will provide a platform for interdisciplinary studies of soft sensors and actuators, including their application in smart textiles, haptic electronics, biomedical devices and soft robotics.
| | |
|
|
|
|
Brief Communications Arising
|
|
| |
|
Measurement-based quantum control of mechanical motion
The displacement of a mechanical resonator is measured to within 35% of the Heisenberg uncertainty limit, enabling feedback cooling to the quantum ground state, nine decibels below the quantum-backaction limit.
Massimiliano Rossi, David Mason, Junxin Chen et al.
|
|
The Moral Machine experiment
Responses from more than two million people to an internet-based survey of attitudes towards moral dilemmas that might be faced by autonomous vehicles shed light on similarities and variations in ethical preferences among different populations.
Edmond Awad, Sohan Dsouza, Richard Kim et al.
|
|
Shared and distinct transcriptomic cell types across neocortical areas
Single-cell transcriptomics of more than 20,000 cells from two functionally distinct areas of the mouse neocortex identifies 133 transcriptomic types, and provides a foundation for understanding the diversity of cortical cell types.
Bosiljka Tasic, Zizhen Yao, Lucas T. Graybuck et al.
|
|
Distinct descending motor cortex pathways and their roles in movement
Transcriptional profiling and axonal reconstructions identify two types of pyramidal tract neuron in the motor cortex: one type projects to thalamic regions and produces early and persistent preparatory activity, and the other type projects to motor centres in the medulla and produces motor commands.
Michael N. Economo, Sarada Viswanathan, Bosiljka Tasic et al.
|
|
|
Security and eavesdropping in terahertz wireless links
Contrary to current expectation, eavesdropping on terahertz wireless data links is shown to be easier than expected, by placing an object in the path of the signal that scatters part of it to a receiver located elsewhere.
Jianjun Ma, Rabi Shrestha, Jacob Adelberg et al.
|
|
Biodiversity increases and decreases ecosystem stability
Species richness was found to increase temporal stability but decrease resistance to warming in an experiment involving 690 micro-ecosystems consisting of 1 to 6 species of bacterivorous ciliates that were sampled over 40 days.
Frank Pennekamp, Mikael Pontarp, Andrea Tabi et al.
|
|
|
|
|
|
