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Genome organization and DNA accessibility control antigenic variation in trypanosomes
Long-read sequencing allows the assembly of antigen-gene arrays in Trypanosoma brucei and, coupled with deletion experiments, demonstrates that histone variants act as a molecular link between genome architecture, chromatin conformation and antigen variation.
Laura S. M. Müller, Raúl O. Cosentino, Konrad U. Förstner et al.
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Chromatin clues to the trypanosome parasite’s uniform coat
The parasite Trypanosoma brucei causes sleeping sickness. It evades human defences by changing the version of a protein that coats its surface. Analysis of its genome and nuclear structure clarifies this variation process.
Steve Kelly,
Mark Carrington
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Cryo-EM structure of the Ebola virus nucleoprotein–RNA complex at 3.6 Å resolution
Near-atomic resolution cryo-electron microscopy structures of the Zaire ebolavirus nucleoprotein indicate a complex transition from the RNA-free to RNA-bound forms of the protein, and reveal the mechanism of oligomer formation and helical assembly.
Yukihiko Sugita, Hideyuki Matsunami, Yoshihiro Kawaoka et al.
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A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour
A dopaminergic mesocortical circuit in juvenile zebra finches detects the presence of an adult zebra finch tutor and helps to encode the performance of the tutor, facilitating the cultural transmission of vocal behaviour.
Masashi Tanaka, Fangmiao Sun, Yulong Li et al.
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Functional genomic landscape of acute myeloid leukaemia
Analyses of samples from patients with acute myeloid leukaemia reveal that drug response is associated with mutational status and gene expression; the generated dataset provides a basis for future clinical and functional studies of this disease.
Jeffrey W. Tyner, Cristina E. Tognon, Daniel Bottomly et al.
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Biodiversity increases and decreases ecosystem stability
Species richness was found to increase temporal stability but decrease resistance to warming in an experiment involving 690 micro-ecosystems consisting of 1 to 6 species of bacterivorous ciliates that were sampled over 40 days.
Frank Pennekamp, Mikael Pontarp, Andrea Tabi et al.
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A cortico-cerebellar loop for motor planning
The cerebellum is critical for the coding of future movement in the frontal cortex.
Zhenyu Gao, Courtney Davis, Alyse M. Thomas et al.
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Proposed early signs of life not set in stone
Efforts to find early traces of life on Earth often focus on structures in ancient rocks, called stromatolites, that formed by microbial activity. One of the oldest proposed stromatolite discoveries has now been questioned.
Mark A. van Zuilen
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Reassessing evidence of life in 3,700-million-year-old rocks of Greenland
In contrast to a previous study of 3,700-million-year-old rocks of the Isua supracrustal belt in Greenland, which presented fossil evidence of stromatolites (macroscopic remains of layered microbial communities), this study shows that these ‘stromatolites’ are features of deformation unconnected to the processes of organic life.
Abigail C. Allwood, Minik T. Rosing, David T. Flannery et al.
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LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
The receptor LILRB4 on monocytic leukaemia cells suppresses T cell activity and supports the infiltration of tumour cells into tissues.
Mi Deng, Xun Gui, Jaehyup Kim et al.
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A two per cent Hubble constant measurement from standard sirens within five years
Gravitational-wave observations of binary neutron-star mergers will enable precision measurements of the Hubble constant within five years.
Hsin-Yu Chen,
Maya Fishbach,
Daniel E. Holz
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From the archive
What Nature was saying 50 and 100 years ago.
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Security and eavesdropping in terahertz wireless links
Contrary to current expectation, eavesdropping on terahertz wireless data links is shown to be easier than expected, by placing an object in the path of the signal that scatters part of it to a receiver located elsewhere.
Jianjun Ma, Rabi Shrestha, Jacob Adelberg et al.
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Transcription factor dimerization activates the p300 acetyltransferase
The activation of the histone acetyltransferase p300 depends on the activation and oligomerization status of transcription factor ligands.
Esther Ortega, Srinivasan Rengachari, Ziad Ibrahim et al.
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A metabolite-derived protein modification integrates glycolysis with KEAP1–NRF2 signalling
Inhibition of the glycolytic enzyme PGK1 using a small molecular probe reveals a molecular link between glycolysis and the KEAP1–NRF2 signalling cascade.
Michael J. Bollong, Gihoon Lee, John S. Coukos et al.
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A protein functionalization platform based on selective reactions at methionine residues
This methionine-selective functionalization strategy uses hypervalent iodine reagents to introduce new groups via the formation of a sulfonium intermediate, which can then undergo further visible-light-mediated reactions to form a diverse range of protein conjugates.
Michael T. Taylor, Jennifer E. Nelson, Marcos G. Suero et al.
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Characterisation of 3D Printed Materials in the Electron Microscope
Wednesday, October 17
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Brief Communications Arising
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Improved limit on the electric dipole moment of the electron
An experimental measurement of the electric dipole moment of the electron with sensitivity an order of magnitude better than previous studies increases the accessible mass range of fundamental particles by a factor of three.
ACME Collaboration
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Battery-operated integrated frequency comb generator
Integrating an optical Kerr frequency comb source with an electronically excited laser pump produces a battery-powered comb generator that does not require external lasers, moveable optics or laboratory set-ups.
Brian Stern, Xingchen Ji, Yoshitomo Okawachi et al.
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Ceramic–metal composites for heat exchangers in concentrated solar power plants
A robust ceramic/refractory metal (ZrC/W)-based composite for use in heat exchangers in concentrated solar power plants above 1,023 kelvin is described, having attractive high-temperature thermal, mechanical and chemical properties combined with cost-effective processing.
M. Caccia, M. Tabandeh-Khorshid, G. Itskos et al.
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Cervical excitatory neurons sustain breathing after spinal cord injury
A population of cervical interneurons is identified that can regulate diaphragm function by modulating phrenic motor neurons; targeting this small population of neurons may be a functional strategy to restore breathing after traumatic spinal cord injury.
Kajana Satkunendrarajah, Spyridon K. Karadimas, Alex M. Laliberte et al.
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