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A randomized
synbiotic trial to prevent sepsis among infants in rural
India
A synbiotic
preparation of Lactobacillus plantarum and
fructooligosaccharide was found to significantly reduce
sepsis and infections of the lower respiratory tract in
a trial involving newborns from rural
India.
Pinaki
Panigrahi, Sailajanandan Parida, Nimai C. Nanda et
al. |
Correction
of a pathogenic gene mutation in human
embryos
CRISPR–Cas9
genome editing is used to induce a DNA repair response
and correct a disease-causing heterozygous mutation in
human embryos with reduced mosaicism and preferential
repair using the wild-type copy of the
gene.
Hong
Ma, Nuria Marti-Gutierrez, Sang-Wook Park et
al. |
The primed
SNARE–complexin–synaptotagmin complex for neuronal
exocytosis
An atomic model
of the primed pre-fusion SNARE–complexin–synaptotagmin-1
complex in neuronal exocytosis accounting for vesicle
priming and cooperation in synchronizing and activating
evoked release on the sub-millisecond
timescale.
Qiangjun
Zhou, Peng Zhou, Austin L. Wang et
al. | |
Large
turbulent reservoirs of cold molecular gas around
high-redshift starburst galaxies
Large haloes of
diffuse molecular gas discovered around high-redshift
starburst galaxies show that galactic feedback, coupled
to turbulence and gravity, extends the starburst phase
instead of quenching it.
E.
Falgarone, M. A. Zwaan, B. Godard et
al. |
Epitaxy of
advanced nanowire quantum devices
A finely tuned
growth strategy to generate nanowire networks that
fulfil all the prerequisites for braiding may lead to a
demonstration of Majorana braiding.
Sasa
Gazibegovic, Diana Car, Hao Zhang et
al. |
Molecular
magnetic hysteresis at 60 kelvin in
dysprosocenium
Magnetic
hysteresis is observed in a dysprosocenium complex at
temperatures of up to 60 kelvin, the origin of which is
the localized metal–ligand vibrational modes unique to
dysprosocenium.
Conrad
A. P. Goodwin, Fabrizio Ortu, Daniel Reta et
al. |
Minimal
geological methane emissions during the Younger
Dryas–Preboreal abrupt warming event
Measurements
from Antarctic ice suggest that geological methane
emissions are much lower than previously thought, and
that methane emissions from hydrates and permafrost in
response to climate warming are minimal.
Vasilii
V. Petrenko, Andrew M. Smith, Hinrich Schaefer et
al. |
Mutation
predicts 40 million years of fly wing
evolution
A detailed
analysis of fly wing phenotypes reveals a strong
positive relationship between variation produced by
mutation, standing genetic variation, and evolutionary
rate over the past 40 million years.
David
Houle, Geir H. Bolstad, Kim van der Linde et
al. |
Stromal
R-spondin orchestrates gastric epithelial stem cells and
gland homeostasis
Myofibroblast-derived
R-spondin 3 orchestrates regeneration of antral stomach
epithelium via Wnt signalling in Axin2+
stem cells.
Michael
Sigal, Catriona Y. Logan, Marta Kapalczynska et
al. |
Polylox
barcoding reveals haematopoietic stem cell fates
realized in vivo
An artificial
recombination locus, Polylox, that can generate
hundreds of thousands of individual barcodes is used to
trace the fates of haematopoietic stem cells in
mice.
Weike
Pei, Thorsten B. Feyerabend, Jens Rössler et
al. |
cGAS
surveillance of micronuclei links genome instability to
innate immunity
The cytoplasmic
DNA sensor cGAS detects DNA in ruptured micronuclei and
activates an innate immune response.
Karen
J. Mackenzie, Paula Carroll, Carol-Anne Martin et
al. |
Mitotic
progression following DNA damage enables pattern
recognition within micronuclei
The authors
report a link between mitosis, the formation of
micronuclei and DNA-damage-induced cGAS-dependent
inflammation.
Shane
M. Harding, Joseph L. Benci, Jerome Irianto et
al. |
CDK4/6
inhibition triggers anti-tumour
immunity
Mouse models of
breast carcinoma and other solid tumours show that
selective cyclin-dependent kinase 4 and 6 (CDK4/6)
inhibitors not only induce tumour cell cycle arrest but
also promote anti-tumour immunity.
Shom
Goel, Molly J. DeCristo, April C. Watt et
al. |
Vaccine-driven
pharmacodynamic dissection and mitigation of
fenethylline psychoactivity
A vaccine-driven
approach shows that the prominent stimulant features of
the psychoactive profile of fenethylline can be
attributed to amphetamine, with synergistic support from
theophylline, and no direct contributions from the
parent drug molecule.
Cody
J. Wenthur, Bin Zhou, Kim D. Janda |
Mechanism of
intracellular allosteric β2AR antagonist
revealed by X-ray crystal structure
The authors
report the crystal structure of the β2
adrenergic receptor in complex with compound 15, an
allosteric modulator that binds to an alternative
binding pocket.
Xiangyu
Liu, Seungkirl Ahn, Alem W. Kahsai et
al. | | |
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