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Communications Arising |
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Charles River has proudly partnered with
the EBD Group to provide the scientific program
for this year's BioPharm America Conference™. Be a
part of this two-day conference that aims to
bridge the gap between drug discovery and
clinical application.
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Quantum
back-action-evading measurement of motion in a negative
mass reference frame
By coupling a
mechanical object to an ensemble of atomic spins with
negative effective mass, the object’s position can be
measured without the usual quantum back-action
perturbation of its momentum.
Christoffer
B. Møller, Rodrigo A. Thomas, Georgios Vasilakis et
al. |
Catalytic allylic
oxidation of internal alkenes to a multifunctional
chiral building block
Non-symmetric
internal alkenes are selectively converted into allylic
functionalized products with high stereoselectivity and
regioselectivity.
Liela
Bayeh, Phong Q. Le, Uttam K. Tambar |
Tundra uptake of
atmospheric elemental mercury drives Arctic mercury
pollution
A two-year study
of mercury deposition in the Arctic finds that the main
source of mercury is gaseous elemental mercury, which is
deposited throughout the year and leads to very high
soil mercury levels.
Daniel
Obrist, Yannick Agnan, Martin Jiskra et
al. |
The pyrite-type
high-pressure form of FeOOH
The pyrite-type
high-pressure form of FeOOH is predicted from first
principles, and found experimentally to be stable under
the conditions at the base of the mantle, with
implications for transport of water within Earth’s deep
interior.
Masayuki
Nishi, Yasuhiro Kuwayama, Jun Tsuchiya et
al. |
Pre-oral gut
contributes to facial structures in non-teleost
fishes
In contrast to
the prevailing belief that the gut begins with the mouth
and continues backwards from there, this work shows that
substantial areas of the faces of ray-finned fishes
originate from the pre-oral gut or
endoderm.
Martin
Minarik, Jan Stundl, Peter Fabian et
al. |
Nutrient sensing
modulates malaria parasite virulence
Malaria
parasites use a sensing mechanism to moderate their
growth in response to the nutrient content of their
host.
Liliana
Mancio-Silva, Ksenija Slavic, Margarida T. Grilo Ruivo
et al. |
An immunogenic
personal neoantigen vaccine for patients with
melanoma
The results of a
phase I trial assessing a personal neoantigen
multi-peptide vaccine in patients with melanoma, showing
feasibility, safety, and immunogenicity.
Patrick
A. Ott, Zhuting Hu, Derin B. Keskin et
al. |
Personalized RNA
mutanome vaccines mobilize poly-specific therapeutic
immunity against cancer
The authors
report the first-in-human application of personalized
neo-antigen RNA vaccines in patients with
melanoma.
Ugur
Sahin, Evelyna Derhovanessian, Matthias Miller et
al. |
Dystrophin–glycoprotein
complex sequesters Yap to inhibit cardiomyocyte
proliferation
After injury in
the heart, postnatal mouse hearts deficient in the Hippo
pathway show efficient repair, and in the hearts of
Mdx mice (a model of Duchenne muscular dystrophy)
Hippo deficiency protects against overload-induced heart
failure.
Yuka
Morikawa, Todd Heallen, John Leach et
al. |
Allelic reprogramming
of 3D chromatin architecture during early mammalian
development
A low-input Hi-C
method is used to show that chromatin organization is
markedly relaxed in pre-implantation mouse embryos after
fertilization and that the subsequent maturation of 3D
chromatin architecture is surprisingly
slow.
Zhenhai
Du, Hui Zheng, Bo Huang et al. |
Liquid droplet
formation by HP1α suggests a role for phase separation
in heterochromatin
Phosphorylation
or DNA binding promotes the physical partitioning of
HP1α out of a soluble aqueous phase into droplets,
suggesting that the repressive action of heterochromatin
may in part be mediated by the phase separation of
HP1.
Adam
G. Larson, Daniel Elnatan, Madeline M. Keenen et
al. |
Phase separation
drives heterochromatin domain formation
HP1a
can nucleate into foci that display liquid properties
during the early stages of heterochromatin domain
formation in Drosophila embryos, suggesting that
the repressive action of heterochromatin may be mediated
in part by emergent properties of phase
separation.
Amy
R. Strom, Alexander V. Emelyanov, Mustafa Mir et
al. | |
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