| |
Abyssal
ocean overturning shaped by seafloor
distribution
The geometry of
the ocean floor sets key regime transitions in the
circulation of deep ocean waters.
C.
de Lavergne, G. Madec, F. Roquet et al.
|
Creation of
forest edges has a global impact on forest
vertebrates
Fragmentation of
forest ecosystems produces forest edges, which affect
the distribution of many analysed vertebrate species;
smaller-bodied amphibians, larger reptiles and
medium-sized mammals experience a larger reduction in
suitable habitat than other forest-core
species.
M.
Pfeifer, V. Lefebvre, C. A. Peres et al.
|
Astrocytic
neuroligins control astrocyte morphogenesis and
synaptogenesis
Astrocyte
morphogenesis depends on interactions between astrocytic
neuroligins and neuronal neurexins.
Jeff
A. Stogsdill, Juan Ramirez, Di Liu et
al. |
Genetic
variation in glia–neuron signalling modulates ageing
rate
Identifying the
gene polymorphisms that are the foundations of variation
in glia–neuron signalling in Caenorhabditis
elegans provides insight into highly variable
age-related declines in worm behaviours.
Jiang-An
Yin, Ge Gao, Xi-Juan Liu et al. |
Structures
of transcription pre-initiation complex with TFIIH and
Mediator
Cryo-electron
microscopy structures of the yeast pre-initiation
complex (PIC) and its complex with core Mediator provide
insights into the opening of promoter DNA and the
initiation of transcription.
S.
Schilbach, M. Hantsche, D. Tegunov et
al. | |
Energetic
eruptions leading to a peculiar hydrogen-rich explosion
of a massive star
Observations of
an event (several energetic eruptions leading to a
terminal explosion that is surprisingly hydrogen-rich)
with the spectrum of a supernova do not match with other
observations of supernovae.
Iair
Arcavi, D. Andrew Howell, Daniel Kasen et
al. |
History-independent
cyclic response of nanotwinned metals
In
copper components containing highly oriented nanotwins,
correlated ‘necklace’ dislocations moving back and forth
offer an unusually fatigue-resistant response to
engineering stress.
Qingsong
Pan, Haofei Zhou, Qiuhong Lu et al.
|
Role of
stacking disorder in ice nucleation
Stacking-disordered
ice crystallites are shown to have an ice nucleation
rate much higher than predicted by classical nucleation
theory, which needs to be taken into account in cloud
modelling.
Laura
Lupi, Arpa Hudait, Baron Peters et al.
|
Detecting
evolutionary forces in language change
Analyses of
digital corpora of annotated texts reveal the influence
of stochastic drift versus selection in grammatical
shifts in English and provide a general method for
quantitatively testing theories of language
change.
Mitchell
G. Newberry, Christopher A. Ahern, Robin Clark et
al. |
Kctd13
deletion reduces synaptic transmission via increased
RhoA
Experimental
evidence that global Kctd13 reduction leads to
increased RhoA levels that reduce synaptic transmission,
implicating RhoA as a potential therapeutic target for
neuropsychiatric disorders associated with copy-number
variants that include KCTD13.
Christine
Ochoa Escamilla, Irina Filonova, Angela K. Walker et
al. |
Fully
integrated silicon probes for high-density recording of
neural activity
New silicon
probes known as Neuropixels are shown to record from
hundreds of neurons simultaneously in awake and freely
moving rodents.
James
J. Jun, Nicholas A. Steinmetz, Joshua H. Siegle et
al. |
Ultra-selective
looming detection from radial motion
opponency
The discovery of
a visual-looming-sensitive neuron, LPLC2, that provides
input to the Drosophila escape pathway, and uses
dendrites patterned to integrate directionally selective
inputs to selectively encode outward
motion.
Nathan
C. Klapoetke, Aljoscha Nern, Martin Y. Peek et
al. |
Nutrient
co-limitation at the boundary of an oceanic
gyre
Nutrient
amendment experiments at the boundary of the South
Atlantic gyre reveal extensive regions in which nitrogen
and iron are co-limiting, with other micronutrients also
approaching co-deficiency; such limitations potentially
increase phytoplankton community
diversity.
Thomas
J. Browning, Eric P. Achterberg, Insa Rapp et
al. |
Drug-tolerant
persister cancer cells are vulnerable to GPX4
inhibition
Cancer persister
cells, which survive cytotoxic treatments, are shown to
be sensitive to inhibition of the lipid hydroperoxidase
GPX4.
Matthew
J. Hangauer, Vasanthi S. Viswanathan, Matthew J. Ryan
et al. |
The
m1A landscape on cytosolic and mitochondrial
mRNA at single-base resolution
Transcriptome-wide
mapping of N1-methyladenosine
(m1A) at single-nucleotide resolution reveals
m1A to be scarce in cytoplasmic mRNA, to
inhibit translation, and to be highly dynamic at a
single site in a mitochondrial mRNA.
Modi
Safra, Aldema Sas-Chen, Ronit Nir et al.
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