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02/05/16 Volume 351, Issue 6273


In this week's issue:


Research Summaries


Editor summaries of this week's papers.

Highlights of the recent literature.


Editorial



In Brief


SCI COMMUN

A roundup of weekly science policy and related news.



In Depth


Infectious Disease

Researchers see many approaches-but a vaccine likely will take years.


Nuclear Nonproliferation

Getting highly enriched uranium out of research reactors will stretch to at least 2035, U.S. study concludes.


Research Funding

The Excellence Initiative is on the right track, a panel says.


Scientific Misconduct

Television documentary raises new questions about Paolo Macchiarini's trachea implants.


Space Science

Galaxy cluster gases, active galactic nuclei, and supernova remnants on ASTRO-H agenda.


Biomedical Research

New journal will publish methods, data, and results.



Feature


The stellar reputation of this small but mighty defense agency rests on the unparalleled clout of its program managers.


New global threats made expertise in the life sciences essential.



Working Life



Letters



Books et al.


Agriculture

An emphasis on consistency and durability over variety and flavor has left many of our favorite foods in peril


Science Lives

Physicist Fang Lizhi recounts his clashes with the Chinese regime and his role in the Tiananmen Square protests



Policy Forum


Science and Society

Engaging a century-long debate about the role of race in science



Perspectives


Ecology

Global expansion and trade contributed to the declining health of honeybees [Also see Report by Wilfert et al.]


Heart Disease

A small molecule inhibits mutated forms of myosin that cause cardiac hypertrophy [Also see Report by Green et al.]


Applied Physics

Antiferromagnets could form a stable and robust platform for future spintronic technology [Also see Report by Wadley et al.]


Stem Cells

Intrinsic epigenetic status and extrinsic environmental factors affect hair follicle stem cells [Also see Research Article by Matsumura et al. and Report by Wang et al.]


Nanomaterials

Hierarchical DNA structures direct the crystallization of gold nanoparticles [Also see Reports by Kim et al. and Liu et al.]


Cryosphere

Radar data reveal how sensitive the Greenland Ice Sheet is to long-term climatic changes [Also see Report by MacGregor et al.]


Retrospective

A Nobel laureate's work on G proteins illuminated how signals are transmitted into cells



Reviews




Research Articles


DNA damage triggers the destruction of type XVII collagen, resulting in hair follicle stem cell depletion and hair loss. [Also see Perspective by Chuong and Lei]



Reports


Nematicity has a temperature dependence that is distinct from that of a related structural distortion in lanthanum-based cuprates.


DNA-coated gold nanoparticles can be controllably and tunably bonded or released from neighboring particles. [Also see Perspective by Tao]


DNA origami is used to create sparsely packed gold nanoparticle superstructures. [Also see Perspective by Tao]


Transport and optical measurements are used to demonstrate the switching of domains in the antiferromagnetic compound CuMnAs. [Also see Perspective by Marrows]


Stiffer ice means slower flow and less rapid thinning in the center of Greenland than in the past. [Also see Perspective by Hvidberg]


Pandemic virus infection in honeybees has been facilitated by the recent spread of a parasitic mite and by human trade. [Also see Perspective by Villalobos]


Reconstruction of 250 years of forest management history shows that Europe's managed forests have contributed to climate warming.


The biophysical effects of recent global forest cover change have caused measurable warming.


A surprising mechanistic insight may lead to drugs targeting an oncogenic form of KRAS expressed in lung cancer.


Structural studies elucidate the mechanism of a reaction that contributes to antibiotic resistance in Gram-negative bacteria.


Dynamic expression of a transcription factor sustains the quiescent cellular state in activated hair follicle stem cells during self-renewal. [Also see Perspective by Chuong and Lei]


A small molecule that reduces cardiac muscle contraction prevents a certain type of heart disease in mice. [Also see Perspective by Warshaw]



New Products


A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.


 
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