Science Table of Contents
 
 
Brought to you by: Bio Rad
Thousands of single cells. One solution.

Single-cell RNA-Seq delivers higher resolution of gene regulation for a deeper view of cell function, disease progression, and identification of therapeutic targets in research compared to RNA-Seq. From the industry leaders in sequencing and Droplet Digital™ technologies, Illumina and Bio-Rad provide a robust, scalable, and user-friendly workflow enabling transcriptome profiling of hundreds to tens of thousands of single cells. Learn more.
 
  
 


VOLUME 354, ISSUE 6313
10th November 2016
 
Science Table of Contents
Research Summaries

This Week in Science
Editor summaries of this week's papers.

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Editors' Choice
Highlights of the recent literature.

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Editorial

Who should direct WHO?
David L. Heymann

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[10.1126/science.aal3456]
 

In Brief

News at a glance
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[10.1126/science.354.6313.686]
 

In Depth

Fusion reactor fuels up with bomb ingredient
W. Wayt Gibbs

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[10.1126/science.354.6313.690]
 

For chronic fatigue syndrome, a 'shifting tide' at NIH
Meredith Wadman

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[10.1126/science.354.6313.691]
 

NSF says: Out with the old telescopes, in with the new
Daniel Clery

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[10.1126/science.354.6313.693]
 

How the body learns to hurt
Emily Underwood

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[10.1126/science.354.6313.694]
 

Study suggests hidden epidemic in CF patients
Kai Kupferschmidt

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[10.1126/science.354.6313.695]
 

Features

The lost norse
Eli Kintisch

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[10.1126/science.354.6313.696]
 

Growing Greenland's archaeologists
Eli Kintisch

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[10.1126/science.354.6313.700]
 

Working Life

The problem with 'alternative'
Maryam Zaringhalam

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[10.1126/science.354.6313.798]
 

Letters

The promise of negative emissions
Klaus S. Lackner

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[10.1126/science.aal2432]
 

The promise of negative emissions-Response
Kevin Anderson , Glen Peters

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[10.1126/science.aal2610]
 

Keeping creationism out of classrooms
Glenn Branch

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[10.1126/science.aal2746]
 

Book Reviews

Tinkering with evolution
Adrian Woolfson

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[10.1126/science.aah5876]
 

Crops on demand
Luis Campos

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[10.1126/science.aai8771]
 

Policy Forum

Precaution and governance of emerging technologies
Gregory E. Kaebnick , Elizabeth Heitman, James P. Collins, Jason A. Delborne, Wayne G. Landis, Keegan Sawyer, Lisa A. Taneyhill, David E. Winickoff

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[10.1126/science.aah5125]
 

Perspectives

Leprosy in red squirrels
Timothy P. Stinear , Roland Brosch

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[10.1126/science.aal0145]
 

Science of the World Wide Web
James Hendler , Wendy Hall

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[10.1126/science.aai9150]
 

Making the cut in the dark genome
Jaclyn M. Einstein , Gene W. Yeo

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[10.1126/science.aak9849]
 

First flu is forever
Cécile Viboud , Suzanne L. Epstein

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[10.1126/science.aak9816]
 

Ammonia activation at a metal
Jessica Hoover

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[10.1126/science.aaj2332]
 

Deborah S. Jin (1968-2016)
Cindy Regal , Jun Ye

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[10.1126/science.aal2545]
 

Review

The broad footprint of climate change from genes to biomes to people
Brett R. Scheffers , Luc De Meester, Tom C. L. Bridge, Ary A. Hoffmann, John M. Pandolfi, Richard T. Corlett, Stuart H. M. Butchart, Paul Pearce-Kelly, Kit M. Kovacs, David Dudgeon, Michela Pacifici, Carlo Rondinini, Wendy B. Foden, Tara G. Martin, Camilo Mora, David Bickford, James E. M. Watson

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[10.1126/science.aaf7671]
 

Research Articles

De novo design of a biologically active amyloid
Rodrigo Gallardo , Meine Ramakers, Frederik De Smet, Filip Claes, Ladan Khodaparast, Laleh Khodaparast, José R. Couceiro, Tobias Langenberg, Maxime Siemons, Sofie Nyström, Laurence J. Young, Romain F. Laine, Lydia Young, Enrico Radaelli, Iryna Benilova, Manoj Kumar, An Staes, Matyas Desager, Manu Beerens, Petra Vandervoort, Aernout Luttun, Kris Gevaert, Guy Bormans, Mieke Dewerchin, Johan Van Eldere, Peter Carmeliet, Greetje Vande Velde, Catherine Verfaillie, Clemens F. Kaminski, Bart De Strooper, Per Hammarström, K. Peter R. Nilsson, Louise Serpell, Joost Schymkowitz, Frederic Rousseau

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[10.1126/science.aah4949]
 

RNA interference is essential for cellular quiescence
B. Roche , B. Arcangioli, R. A. Martienssen

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[10.1126/science.aah5651]
 

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting
Katelyn M. Gostic , Monique Ambrose, Michael Worobey, James O. Lloyd-Smith

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[10.1126/science.aag1322]
 

Reports

Single-molecule optomechanics in "picocavities"
Felix Benz , Mikolaj K. Schmidt, Alexander Dreismann, Rohit Chikkaraddy, Yao Zhang, Angela Demetriadou, Cloudy Carnegie, Hamid Ohadi, Bart de Nijs, Ruben Esteban, Javier Aizpurua, Jeremy J. Baumberg

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[10.1126/science.aah5243]
 

Coordination-induced weakening of ammonia, water, and hydrazine X-H bonds in a molybdenum complex
Máté J. Bezdek , Sheng Guo, Paul J. Chirik

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[10.1126/science.aag0246]
 

Attosecond dynamics through a Fano resonance: Monitoring the birth of a photoelectron
V. Gruson , L. Barreau, Á. Jiménez-Galan, F. Risoud, J. Caillat, A. Maquet, B. Carré, F. Lepetit, J.-F. Hergott, T. Ruchon, L. Argenti, R. Taïeb, F. Martín, P. Salières

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[10.1126/science.aah5188]
 

Observing the ultrafast buildup of a Fano resonance in the time domain
A. Kaldun , A. Blättermann, V. Stooß, S. Donsa, H. Wei, R. Pazourek, S. Nagele, C. Ott, C. D. Lin, J. Burgdörfer, T. Pfeifer

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[10.1126/science.aah6972]
 

A bioinspired iron catalyst for nitrate and perchlorate reduction
Courtney L. Ford , Yun Ji Park, Ellen M. Matson, Zachary Gordon, Alison R. Fout

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[10.1126/science.aah6886]
 

Red squirrels in the British Isles are infected with leprosy bacilli
Charlotte Avanzi , Jorge del-Pozo, Andrej Benjak, Karen Stevenson, Victor R. Simpson, Philippe Busso, Joyce McLuckie, Chloé Loiseau, Colin Lawton, Janne Schoening, Darren J. Shaw, Jérémie Piton, Lucio Vera-Cabrera, Jesùs S. Velarde-Felix, Fergal McDermott, Stephen V. Gordon, Stewart T. Cole, Anna L. Meredith

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[10.1126/science.aah3783]
 

Observed Arctic sea-ice loss directly follows anthropogenic CO2 emission
Dirk Notz , Julienne Stroeve

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[10.1126/science.aag2345]
 

Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Josephine M. Bryant , Dorothy M. Grogono, Daniela Rodriguez-Rincon, Isobel Everall, Karen P. Brown, Pablo Moreno, Deepshikha Verma, Emily Hill, Judith Drijkoningen, Peter Gilligan, Charles R. Esther, Peadar G. Noone, Olivia Giddings, Scott C. Bell, Rachel Thomson, Claire E. Wainwright, Chris Coulter, Sushil Pandey, Michelle E. Wood, Rebecca E. Stockwell, Kay A. Ramsay, Laura J. Sherrard, Timothy J. Kidd, Nassib Jabbour, Graham R. Johnson, Luke D. Knibbs, Lidia Morawska, Peter D. Sly, Andrew Jones, Diana Bilton, Ian Laurenson, Michael Ruddy, Stephen Bourke, Ian C. J. W. Bowler, Stephen J. Chapman, Andrew Clayton, Mairi Cullen, Owen Dempsey, Miles Denton, Maya Desai, Richard J. Drew, Frank Edenborough, Jason Evans, Jonathan Folb, Thomas Daniels, Helen Humphrey, Barbara Isalska, Søren Jensen-Fangel, Bodil Jönsson, Andrew M. Jones, Terese L. Katzenstein, Troels Lillebaek, Gordon MacGregor, Sarah Mayell, Michael Millar, Deborah Modha, Edward F. Nash, Christopher O'Brien, Deirdre O'Brien, Chandra Ohri, Caroline S. Pao, Daniel Peckham, Felicity Perrin, Audrey Perry, Tania Pressler, Laura Prtak, Tavs Qvist, Ali Robb, Helen Rodgers, Kirsten Schaffer, Nadia Shafi, Jakko van Ingen, Martin Walshaw, Danie Watson, Noreen West, Joanna Whitehouse, Charles S. Haworth, Simon R. Harris, Diane Ordway, Julian Parkhill, R. Andres Floto

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[10.1126/science.aaf8156]
 

Neural correlates of ticklishness in the rat somatosensory cortex
S. Ishiyama , M. Brecht

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[10.1126/science.aah5114]
 

Detection of human adaptation during the past 2000 years
Yair Field , Evan A Boyle, Natalie Telis, Ziyue Gao, Kyle J. Gaulton, David Golan, Loic Yengo, Ghislain Rocheleau, Philippe Froguel, Mark I. McCarthy, Jonathan K. Pritchard

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[10.1126/science.aag0776]
 

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
Bo Hu , Chengcheng Jin, Hua-Bing Li, Jiyu Tong, Xinshou Ouyang, Naniye Malli Cetinbas, Shu Zhu, Till Strowig, Fred C. Lam, Chen Zhao, Jorge Henao-Mejia, Omer Yilmaz, Katherine A. Fitzgerald, Stephanie C. Eisenbarth, Eran Elinav, Richard A. Flavell

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[10.1126/science.aaf7532]
 

Systematic mapping of functional enhancer-promoter connections with CRISPR interference
Charles P. Fulco , Mathias Munschauer, Rockwell Anyoha, Glen Munson, Sharon R. Grossman, Elizabeth M. Perez, Michael Kane, Brian Cleary, Eric S. Lander, Jesse M. Engreitz

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[10.1126/science.aag2445]
 

New Products

New Products
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[10.1126/science.354.6313.775-a]
 

From the Office of Publishing

Webinar | Deciphering cancer: Genomic instability in cancer
Mark J. O'Connor , Johnathan R. Whetstine

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[10.1126/science.354.6313.775-b]
 

First Release
 
First Release
Selected Science papers are published online ahead of print. Some editorial changes may occur between the online version and the final printed version.

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Brought to you by: Bio Rad
Thousands of single cells. One solution.

Single-cell RNA-Seq delivers higher resolution of gene regulation for a deeper view of cell function, disease progression, and identification of therapeutic targets in research compared to RNA-Seq. From the industry leaders in sequencing and Droplet Digital™ technologies, Illumina and Bio-Rad provide a robust, scalable, and user-friendly workflow enabling transcriptome profiling of hundreds to tens of thousands of single cells. Learn more.