nature

THIS WEEK

Editorials

Biosafety in the balance ▶

An accident with anthrax demonstrates that pathogen research always carries a risk of release — and highlights the need for rigorous scrutiny of gain-of-function flu studies.

Metrics market ▶

Measures of research impact are improving, but universities should be wary of their limits.

Storm warning ▶

Environmentalists are divided over whether it is possible to have a ‘good’ Anthropocene.

World View

Rural students are being left behind in China ▶

As the education gap between city and countryside widens, young people face an invisible barrier to scientific research, says Qiang Wang.

Seven Days

Seven days: 20–26 June 2014 ▶

NEWS IN FOCUS

NASA carbon-monitoring orbiter readies for launch ▶

Satellite will map sources and sinks of greenhouse gas in unprecedented detail.

Africa science plan attacked ▶

Proposed innovation strategy is low on detail and commitments from governments.

Resurrected cancer drug faces regulators ▶

Despite a chequered history, olaparib is finally before the US Food and Drug Administration.

‘Life on Earth’ project gets under way ▶

Assessments by international biodiversity group aim to halt damage to world’s ecosystems.

Brain wave hits California ▶

State creates programme to boost neuroscience innovation.

Features

Love in the lab: Close collaborators ▶

Romance often sparks between colleagues, and scientists are no different. Nature profiles four super-couples who have combined love and the lab.

Nutrition: Vitamins on trial ▶

After decades of study, researchers still can't agree on whether nutritional supplements actually improve health.

COMMENT

Energy: Consider the global impacts of oil pipelines ▶

Debates over oil-sands infrastructure obscure a broken policy process that overlooks broad climate, energy and environment issues, warn Wendy J. Palen and colleagues.

Physics: Bell’s theorem still reverberates ▶

Fifty years ago, John Bell made metaphysics testable, but quantum scientists still dispute the implications. Howard Wiseman proposes a way forward.

Books and Arts

Bibliometrics: The citation game ▶

Jonathan Adams takes the measure of the uses and misuses of scholarly impact.

Books in brief ▶

Space science: Lunar star ▶

Roger D. Launius is perplexed by a biography of Neil Armstrong that profiles the missions, not the man.

Correspondence

Socio-economics: Assess benefits and costs of shale energy Thomas G. Measham, David A. Fleming | Ancient cultures: Maize is not a clue to Puerto Rican origins Jaime R. Pagán-Jiménez, Reniel Rodríguez-Ramos, José R. Oliver | Research output: Greek science must reform to survive Nikolaos Vrachnis, Nikolaos Vlachadis, Dionisios Vrachnis | Embryo screening: Update German view of genetic testing Peter Propping, Heinz Schott

Obituary

Gerald Edelman (1929–2014) ▶

Biologist who won Nobel for solving antibody structure.

Correction

Correction ▶

RESEARCH

Latest Online

Cancer: Sugar-coated cell signalling ▶

Andrew J. Ewald, Mikala Egeblad

Immunology: Fixing the odds against tuberculosis ▶

Samuel M. Behar, Christopher M. Sassetti

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma ▶

Paul A. Northcott, Catherine Lee, Thomas Zichner et al.

Focusing on two ill-characterized subtypes of medulloblastoma (group 3 and group 4), this study identifies prevalent genomic structural variants that are restricted to these two subtypes and independently bring together coding regions of GFI1 family proto-oncogenes with active enhancer elements, leading to their mutually exclusive oncogenic activation.

The cancer glycocalyx mechanically primes integrin-mediated growth and survival ▶

Matthew J. Paszek, Christopher C. DuFort, Olivier Rossier et al.

Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins, and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins — by funnelling integrins into adhesions, integrin clustering and signalling is promoted, which leads to enhanced cell survival and proliferation.

NMDA receptor structures reveal subunit arrangement and pore architecture ▶

Chia-Hsueh Lee, Wei Lü, Jennifer Carlisle Michel et al.

X-ray crystal structures are presented of the N-methyl-d-aspartate (NMDA) receptor, a calcium-permeable ion channel that opens upon binding of glutamate and glycine; glutamate is a key excitatory neurotransmitter and enhanced structural insight of this receptor may aid development of therapeutic small molecules.

PVT1 dependence in cancer with MYC copy-number increase ▶

Yuen-Yi Tseng, Branden S. Moriarity, Wuming Gong et al.

Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis.

Equalizing excitation–inhibition ratios across visual cortical neurons ▶

Mingshan Xue, Bassam V. Atallah, Massimo Scanziani

Different amounts of excitation received by different pyramidal cells of primary visual cortex are matched by proportional amounts of inhibition.

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 ▶

Jing Y. Krzeszinski, Wei Wei, HoangDinh Huynh et al.

A microRNA, miR-34a, is a novel and critical suppressor of osteoclastogenesis, bone resorption and the bone metastatic niche.

Visualizing the kinetic power stroke that drives proton-coupled zinc(ii) transport ▶

Sayan Gupta, Jin Chai, Jie Cheng et al.

In the transport cycle of Yiip, zinc(ii) binding triggers a highly localized, all-or-nothing change of water accessibility to the transport site and an adjacent hydrophobic gate.

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms ▶

Lorena Arranz, Abel Sánchez-Aguilera, Daniel Martín-Pérez et al.

Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

A vaccine targeting mutant IDH1 induces antitumour immunity ▶

Theresa Schumacher, Lukas Bunse, Stefan Pusch et al.

The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor ▶

Nicholas Kwiatkowski, Tinghu Zhang, Peter B. Rahl et al.

Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs.

Visualization of arrestin recruitment by a G-protein-coupled receptor ▶

Arun K. Shukla, Gerwin H. Westfield, Kunhong Xiao et al.

Single-particle electron microscopy and hydrogen–deuterium exchange mass spectrometry are used to characterize the structure and dynamics of a G-protein-coupled receptor–arrestin complex.

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations ▶

Ofer Fridman, Amir Goldberg, Irine Ronin et al.

Repeated exposure of the bacterium Escherichia coli to clinically relevant concentrations of ampicillin results in the evolution of tolerance—the ability to survive until the antibiotic concentration diminishes—through an extension of the lag phase, a finding that has implications for slowing the evolution of antibiotic resistance.

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk ▶

Katrin D. Mayer-Barber, Bruno B. Andrade, Sandra D. Oland et al.

Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that interleukin-1 enhances the production of prostaglandin E2, which helps contain the pathogen while also suppressing detrimental type I interferon.

Cooperating with the future ▶

Oliver P. Hauser, David G. Rand, Alexander Peysakhovich et al.

An intergenerational cooperation game has been developed to study decision-making regarding resource use: when decisions about resource extraction were made individually the resource was rapidly depleted by a minority of defectors; the resource was sustainably maintained across generations, however, when decisions were made democratically by voting.

Articles and Letters

Aspergillomarasmine A overcomes metallo-β-lactamase antibiotic resistance ▶

Andrew M. King, Sarah A. Reid-Yu, Wenliang Wang et al.

The emergence of Gram-negative pathogens resistant to carbapenem antibiotics is a global health concern and carbapenem resistance often arises through acquisition of β-lactamase enzymes; this study identifies the natural fungal product aspergillomarasmine A as a metallo-β-lactamase inhibitor and a potential treatment to tackle carbapenem resistance.

The selective tRNA aminoacylation mechanism based on a single G•U pair ▶

Masahiro Naganuma, Shun-ichi Sekine, Yeeting Esther Chong et al.

X-ray crystal structures of a tRNA synthetase bound to wild-type and mutant alanine tRNAs reveal the structural basis for selectivity.

Structure of a modular polyketide synthase ▶

Somnath Dutta, Jonathan R. Whicher, Douglas A. Hansen et al.

Polyketide synthases are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to establish the structure of a bacterial full-length module, and to elucidate the structural basis of both intramodule and intermodule substrate transfer.

Purkinje-cell plasticity and cerebellar motor learning are graded by complex-spike duration ▶

Yan Yang, Stephen G. Lisberger

Recordings from monkeys during motor learning suggest that durations of complex-spike (CS) responses to climbing-fibre inputs are meaningful signals correlated across the Purkinje-cell population during motor learning; longer climbing-fibre bursts lead to longer-duration CS responses, larger synaptic depression and stronger learning, thus forming a graded instruction.

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells ▶

Mitsutoshi Yamada, Bjarki Johannesson, Ido Sagi et al.

Here human embryonic stem cell lines are derived by somatic cell nuclear transfer from cells of a newborn and from skin cells of an adult, a female with type 1 diabetes; the stem cells produced are pluripotent and can be differentiated into insulin-producing beta cells.

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing ▶

Volker Hovestadt, David T. W. Jones, Simone Picelli et al.

Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from human and mouse tumours, coupled with analysis of histone modifications, RNA transcripts and genome sequencing, uncovers a wealth of alterations that provide insights into the epigenetic regulation of transcription and genome organization in medulloblastoma pathogenesis.

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase ▶

Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi et al.

Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase.

Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression ▶

Yoonjin Lee, John E. Dominy, Yoon Jong Choi et al.

Formation of an active cyclin D1–Cdk4 complex suppresses glucose metabolism independently of cell division.

Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer ▶

Curtis M. Schauder, Xudong Wu, Yasunori Saheki et al.

Several proteins localized at membrane contact sites contain an SMP domain, which has been proposed to act as a lipid-binding module; here, the crystal structure of a fragment of the extended synaptotagmin 2 protein, including its SMP, is presented, and indicates that this protein may have a direct role in lipid transport.

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks ▶

Nicholas A. Willis, Gurushankar Chandramouly, Bin Huang et al.

Direct evidence for the role of BRCA1 in controlling homologous recombination at stalled replication forks has been obtained in mammalian cells using the bacterial Tus/Ter system.

Structural rearrangements of a polyketide synthase module during its catalytic cycle ▶

Jonathan R. Whicher, Somnath Dutta, Douglas A. Hansen et al.

Polyketide synthases (PKSs) are multidomain enzymes that produce polyketides, which form the basis of many therapeutic agents; here, electron cryo-microscopy is used to probe the structure of an intact module of a multi-enzyme PKS in different functional states.

News & Views

Antibiotic resistance: To the rescue of old drugs ▶

Djalal Meziane-Cherif, Patrice Courvalin

Structural biology: Wobble puts RNA on target ▶

Oscar Vargas-Rodriguez, Karin Musier-Forsyth

Structural biology: Enzyme assembly line pictured ▶

Peter F. Leadlay

Cancer: Sugar-coated cell signalling ▶

Andrew J. Ewald, Mikala Egeblad

Behavioural economics: A caring majority secures the future ▶

Louis Putterman

Immunology: Fixing the odds against tuberculosis ▶

Samuel M. Behar, Christopher M. Sassetti

Erratum

Erratum: CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation ▶

Emmanuel Martin, Noé Palmic, Sylvia Sanquer et al.

Research Highlights

Animal behaviour: Magnetic compass guides butterflies | Cardiovascular biology: Mutations lower heart-disease risk | Neuroscience: Brain circuit spurs social behaviour | Anthropology: To and from the Horn of Africa | Neuroscience: Tanning might be addictive | Secret publishing deals exposed

NEWS & COMMENT

Biosafety in the balance | ‘Life on Earth’ project gets under way | Nutrition: Vitamins on trial | Books in brief | Embryo screening: Update German view of genetic testing | Gerald Edelman (1929–2014) | Resurrected cancer drug faces regulators | Brain wave hits California

More Biological Sciences ▶

RESEARCH

Latest Online

Cancer: Sugar-coated cell signalling ▶

Andrew J. Ewald, Mikala Egeblad

Immunology: Fixing the odds against tuberculosis ▶

Samuel M. Behar, Christopher M. Sassetti

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma ▶

Paul A. Northcott, Catherine Lee, Thomas Zichner et al.

Focusing on two ill-characterized subtypes of medulloblastoma (group 3 and group 4), this study identifies prevalent genomic structural variants that are restricted to these two subtypes and independently bring together coding regions of GFI1 family proto-oncogenes with active enhancer elements, leading to their mutually exclusive oncogenic activation.

The cancer glycocalyx mechanically primes integrin-mediated growth and survival ▶

Matthew J. Paszek, Christopher C. DuFort, Olivier Rossier et al.

Metastatic cancer cells are shown to have a tendency towards forming a bulky glycocalyx owing to the production of large glycoproteins, and this cancer-associated glycocalyx has a mechanical effect on the spatial organization of integrins — by funnelling integrins into adhesions, integrin clustering and signalling is promoted, which leads to enhanced cell survival and proliferation.

PVT1 dependence in cancer with MYC copy-number increase ▶

Yuen-Yi Tseng, Branden S. Moriarity, Wuming Gong et al.

Pvt1 overexpression in mice contributes to high Myc levels due to 8q24.21 gain and to MYC-driven tumorigenesis.

miR-34a blocks osteoporosis and bone metastasis by inhibiting osteoclastogenesis and Tgif2 ▶

Jing Y. Krzeszinski, Wei Wei, HoangDinh Huynh et al.

A microRNA, miR-34a, is a novel and critical suppressor of osteoclastogenesis, bone resorption and the bone metastatic niche.

Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms ▶

Lorena Arranz, Abel Sánchez-Aguilera, Daniel Martín-Pérez et al.

Myeloproliferative neoplasms are caused by mutations in the haematopoietic stem cell (HSC) compartment, and here the authors show that the HSC niche contributes to the pathogenesis; sympathetic innervation of mesenchymal stem cells (MSCs) is reduced in the bone marrow of patients, which leads to reduced MSC numbers and increased mutant HSC expansion, and restoring sympathetic regulation of MSCs with neuroprotective/sympathomimetic drugs prevents mutant HSC expansion.

A vaccine targeting mutant IDH1 induces antitumour immunity ▶

Theresa Schumacher, Lukas Bunse, Stefan Pusch et al.

The mutant IDH1 protein, which is expressed in a large fraction of human gliomas, is shown to be immunogenic; mutant-specific immune responses can be detected in patients with IDH1 mutated gliomas and generated in mice and are shown to treat established IDH1 mutant tumours in a syngeneic MHC humanized mouse model in a CD4 T-cell-dependent manner.

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor ▶

Nicholas Kwiatkowski, Tinghu Zhang, Peter B. Rahl et al.

Here, a covalent inhibitor targeting cyclin-dependent kinase 7 (CDK7) demonstrates in vitro and in vivo efficacy against T-cell acute lymphoblastic leukaemia by downregulating oncogenic transcriptional programs.

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk ▶

Katrin D. Mayer-Barber, Bruno B. Andrade, Sandra D. Oland et al.

Active tuberculosis has been linked to excessive type I interferon induction whereas interleukin-1 may have protective effects; here it is shown that interleukin-1 enhances the production of prostaglandin E2, which helps contain the pathogen while also suppressing detrimental type I interferon.

Articles and Letters

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing ▶

Volker Hovestadt, David T. W. Jones, Simone Picelli et al.

Medulloblastoma is a malignant childhood brain tumour presenting major clinical challenges; here, a comprehensive genome-wide DNA methylation data set from human and mouse tumours, coupled with analysis of histone modifications, RNA transcripts and genome sequencing, uncovers a wealth of alterations that provide insights into the epigenetic regulation of transcription and genome organization in medulloblastoma pathogenesis.

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase ▶

Anila K. Madiraju, Derek M. Erion, Yasmeen Rahimi et al.

Metformin treatment of rats at physiologically relevant doses inhibits the redox shuttle enzyme mitochondrial glycerophosphate dehydrogenase.

BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks ▶

Nicholas A. Willis, Gurushankar Chandramouly, Bin Huang et al.

Direct evidence for the role of BRCA1 in controlling homologous recombination at stalled replication forks has been obtained in mammalian cells using the bacterial Tus/Ter system.

News & Views

Cancer: Sugar-coated cell signalling ▶

Andrew J. Ewald, Mikala Egeblad

Immunology: Fixing the odds against tuberculosis ▶

Samuel M. Behar, Christopher M. Sassetti

Erratum

Erratum: CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation ▶

Emmanuel Martin, Noé Palmic, Sylvia Sanquer et al.

Research Highlights

Cardiovascular biology: Mutations lower heart-disease risk

NEWS & COMMENT

Biosafety in the balance | Nutrition: Vitamins on trial | Resurrected cancer drug faces regulators

More Health Sciences ▶

RESEARCH

Latest Online

Astrophysics: A tight duo in a trio of black holes ▶

Greg Taylor

A low-cost non-toxic post-growth activation step for CdTe solar cells ▶

J. D. Major, R. E. Treharne, L. J. Phillips et al.

MgCl₂ is shown to be a cheap and non-toxic replacement for the costly and environmentally unfriendly salt CdCl₂ that has long been used as the ‘activation’ step in the production of cadmium telluride solar cells.

A close-pair binary in a distant triple supermassive black hole system ▶

R. P. Deane, Z. Paragi, M. J. Jarvis et al.

A triple supermassive black hole system has been found that shows helical modulation of the large-scale radio jets; this modulation is caused by two of the black holes being tightly coupled as a binary system.

Articles and Letters

A zero-knowledge protocol for nuclear warhead verification ▶

Alexander Glaser, Boaz Barak, Robert J. Goldston

Future rounds of nuclear arms control would ideally involve direct inspection of nuclear warheads using procedures that give inspectors high confidence about the authenticity of submitted nuclear items yet give no information about their design; this is now shown to be achievable using zero-knowledge protocols in neutron imaging of nuclear warheads.

Precision measurement of the Newtonian gravitational constant using cold atoms ▶

G. Rosi, F. Sorrentino, L. Cacciapuoti et al.

Determination of the gravitational constant G using laser-cooled atoms and quantum interferometry, a technique that gives new insight into the systematic errors that have proved elusive in previous experiments, yields a value that has a relative uncertainty of 150 parts per million and which differs from the current recommended value by 1.5 combined standard deviations.

Chirality-specific growth of single-walled carbon nanotubes on solid alloy catalysts ▶

Feng Yang, Xiao Wang, Daqi Zhang et al.

Single-walled carbon nanotubes of a single chirality can be produced with an abundance of more than 92 per cent when using tungsten-based bimetallic alloy nanocrystals as catalysts.

Reviews and Perspectives

An overview of N-heterocyclic carbenes ▶

Matthew N. Hopkinson, Christian Richter, Michael Schedler et al.

N-heterocyclic carbenes are powerful tools in organic chemistry, with many commercially important applications; this overview describes their properties and potential uses.

News & Views

Nuclear-weapons dismantlement: Identifying a hidden warhead ▶

John Finney, James M. Acton

Fundamental constants: A cool way to measure big G ▶

Stephan Schlamminger

Applied physics: Trawling for complements ▶

J. Marty Gregg, Amit Kumar

Astrophysics: A tight duo in a trio of black holes ▶

Greg Taylor

Research Highlights

Organic chemistry: Microbes pitch in with synthesis | Astronomy: Speedy stars revealed nearby | Secret publishing deals exposed

NEWS & COMMENT

Energy: Consider the global impacts of oil pipelines | Bibliometrics: The citation game | Books in brief | Space science: Lunar star | Socio-economics: Assess benefits and costs of shale energy | Physics: Bell’s theorem still reverberates

More Physical Sciences ▶

RESEARCH

Latest Online

Cooperating with the future ▶

Oliver P. Hauser, David G. Rand, Alexander Peysakhovich et al.

An intergenerational cooperation game has been developed to study decision-making regarding resource use: when decisions about resource extraction were made individually the resource was rapidly depleted by a minority of defectors; the resource was sustainably maintained across generations, however, when decisions were made democratically by voting.

Articles and Letters

South Greenland ice-sheet collapse during Marine Isotope Stage 11 ▶

Alberto V. Reyes, Anders E. Carlson, Brian L. Beard et al.

The isotopic composition of glacial sediment discharged into the ocean from south Greenland is used to identify a major reduction in the amount of that sediment derived from erosion of Greenland’s Precambrian bedrock, probably indicating the cessation of subglacial erosion and sediment transport during Marine Isotope Stage 11 as a result of the almost complete deglaciation of south Greenland.

Research Highlights

Atmospheric science: Arctic heat lessens cold snaps | Climate science: Warming could boost air pollution

NEWS & COMMENT

Storm warning | NASA carbon-monitoring orbiter readies for launch | ‘Life on Earth’ project gets under way | Energy: Consider the global impacts of oil pipelines | Socio-economics: Assess benefits and costs of shale energy

More Earth & Environmental Sciences ▶

Stroke ▶

Brian Owens

Statistics: A growing global burden ▶

Stroke is a public-health problem that tends to affect poorer countries more and leaves richer countries with ballooning medical costs. Yet it is often preventable. By Zoë Corbyn.

Perspective: Time to tackle blood pressure ▶

Simply lowering blood pressure would reduce the risk of both stroke and age-related cognitive impairment, says Walter J. Koroshetz.

First response: Race against time ▶

Mobile stroke units can save lives by treating people before any damage starts to take hold.

Drug delivery: Brain food ▶

The key to stroke recovery is to coax the brain cells to heal without creating more damage in the process. A clever delivery system may just do the trick.

Rehabilitation: Machine recovery ▶

Interactive devices are helping people who have had a stroke to regain their motor function.

Mental health: Ups and downs ▶

Strokes can shatter a person's identity and make it difficult to find the light. But there are ways to help patients cope.

Perspective: Silent, but preventable, perils ▶

'Covert' strokes are a leading cause of dementia — and their incidence will rise in step with that of vascular risk factors, says Antoine M. Hakim.

Sponsor

Symposia: Behind the scenes ▶

Early-career researchers who help to organize conferences develop crucial skills that go beyond just booking speakers.

Turning point: Katharine Hayhoe ▶

Christian scientist spreads message about climate change.

Funding: Salk windfall ▶

Opportunities for researchers open in California.

Recruitment: Sweden looks abroad ▶

Government grant leads to hiring drive for international scientists.

Job sharing: Game of clones ▶

Canadian professors bring attention to divide between administration and faculty members.

Careers related news & comment

Metrics market | Rural students are being left behind in China Qiang Wang | Seven days: 20–26 June 2014 | Bibliometrics: The citation game Jonathan Adams | Research output: Greek science must reform to survive Nikolaos Vrachnis, Nikolaos Vlachadis, Dionisios Vrachnis | Resurrected cancer drug faces regulators Heidi Ledford

Research Investigators in Pharmacology Research Investigator on Intestinal Flora in Health and Disease Formulation Scientists (Microencapsulation)

Qingdao Eastsea Pharmaceutical Co., Ltd. 

Research Technician

University of Sussex 

Postdoctoral Fellow

Mayo Clinic 

Marie Curie Post-doctoral Fellowships

Human Genetics Foundation 

4th Monash Cardiovascular Symposium

6 October 2014 Melbourne, Australia