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Antibody Validation Roundtable: Specificity + Sensitivity + Reproducibility = Validation

Wednesday, December 3, 2014, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Learn how antibody data reproducibility issues impact academia, industry, and publishing. Panelists include Science Editor-in-Chief, Marcia McNutt.

Register TODAY: webinar.sciencemag.org
Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technologies.

Science/AAAS
Science
Table of Contents
 

21 November 2014 Volume 346, Issue 6212




In this week's issue:


Special Section


Introduction to Special Issue
Skin

From bench to bedside


Special Issue News
Skin

Nina Jablonski explores how it evolved—and what happens when it does not match the environment.


Special Issue Review






Research Summaries


Editor summaries of this week's papers.

Highlights of the recent literature.


Editorial



In Brief


A roundup of weekly science policy and related news.



In Depth


Planetary Science

Elation and disappointment as lander goes into early hibernation, curtailing experiments.


Human Behavior

Replication of 1993 study highlights same region on X chromosome, but some still call evidence inconclusive.


Climate Policy

Modelers move to analyze implications of largest emitter's commitment to stabilize emissions by 2030.


Europe

New European Commission says it hasn't decided how it will organize its scientific advice.



Feature


Astronomers thought they knew why all galaxies eventually redden and die. They were wrong.


Does any treatment work against Ebola? Researchers may soon find out, if they can overcome daunting ethical and practical challenges.


A push for improving basic care of Ebola patients could save many lives without experimental treatments.



Working Life




Letters



Books et al.


Restoration Ecology

Exhibition

A listing of books received at Science during the week ending 14 November 2014.



Policy Forum


Ecosystems Management

Massive seawall construction in coastal wetlands threatens biodiversity

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Perspectives


Neuroscience

Research exploring sex differences in the human brain must overcome “neurosexist” interpretations


Nuclear Materials

Levitated droplets of uranium oxide reveal a complex structure below and above the melting point [Also see Report by Skinner et al.]


Geophysics

Data from the eastern Himalaya challenge the idea that climate-driven erosion can control tectonics [Also see Report by Wang et al.]


Immunology

How does influenza immunity develop over one's lifetime? [Also see Report by Fonville et al.]


Circadian Rhythms

A circadian gene expression atlas shows that time of day is relevant to the oscillation of drug targets and the effects of medications


Developmental Biology

Specific mechanisms of somatic growth protect long-lived fungi and plants from deleterious mutations



Research Articles


The presence of a DNA “exit gate” in a tripartite ring of proteins confirms that the ring holds together sister chromatid DNA strands.


The presence of a DNA “exit gate” in a tripartite ring of proteins confirms the ring holds together sister chromatid DNA strands.



Reports


Anti-HIV nucleoside analogs treat retinal degeneration and graft-versus-host disease in mice.


The enhancer landscape controlling Hoxd genes in digit and external genital cells is the same.


Mouse-to-human genomic comparisons illuminate conserved transcriptional programs despite regulatory rewiring.


The interplay between gain and loss can provide a route to control laser emission.


The interplay between gain and loss can provide a route to control laser emission.


Sediment cores from a buried canyon upstream of the Tsangpo Gorge support a rapid uplift event to explain gorge formation. [Also see Perspective by Whipple]


An exoplanet’s magnetic field is manifested as a particular absorption pattern in the transmitted spectrum of the host star.


Levitation of molten uranium dioxide allowed structural determination of the solid and melt at high temperature. [Also see Perspective by Navrotsky]


Intercrossed mice infected with Ebola virus show a spectrum of pathology from prolonged coagulation to total resistance.


A combination of hygienic practices could feasibly check Ebola within 6 months.


Preemptive vaccine updates may substantially improve influenza vaccine efficacy in previously exposed individuals. [Also see Perspective by Lessler]



Podcast


On this week's show: Neurosexism and a news roundup.



New Products


A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.



From the AAAS Office of Publishing and Member Services


Business Office Feature

 
  Science - Cover
About the Cover

Also Online:
Science Express
Daily News
Science Careers
Science Signaling
Science Translational Medicine



Podcast

On this week's show: Neurosexism and a news roundup.

Listen now.

Video Portal

Watch videos on the fine-tuning of facial features by DNA enhancers, a mouse immune to a scorpion's sting, and more at the Science Video Portal.
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New Science/AAAS Webinar and Science Signaling Webinar
Antibody Validation Roundtable: Specificity + Sensitivity + Reproducibility = Validation

Wednesday, December 3, 2014, at 9 a.m. Pacific, 12 noon Eastern, 5 p.m. UK, 6 p.m. Central Europe Learn how antibody data reproducibility issues impact academia, industry, and publishing. Panelists include Science Editor-in-Chief, Marcia McNutt.

Register TODAY: webinar.sciencemag.org
Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technologies.


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