nature alert

Think big ▶

The best way to manage national parks in the face of the effects of climate change is not to manage at the park level, but to work with landscapes. A new US initiative shows the way. Read Editorial ▶

Different strokes ▶

Scientists in Romania and Bulgaria are having the best and the worst of times. Read Editorial ▶

First do no harm ▶

Simple tools to diagnose mental illness should not be offered without sound supporting evidence. Read Editorial ▶

University cuts show science is far from saved ▶

Scientific leaders have been too quick to praise the reprieve for research money, says Colin Macilwain. The slashing of teaching funds will do real damage. Read Column ▶

Seven days: 13 January 2011 ▶

The week in science Read Seven Days ▶

Cancer trial errors revealed ▶

University officials admit data withheld from review panel before misconduct charges arose. Read News ▶

Tevatron faces final curtain ▶

Particle accelerator to be switched off this year, as lack of funds spells the end for US bid to capture Higgs particle. Read News ▶

Science fortunes of Balkan neighbours diverge ▶

Romanian researchers' prospects improve, whereas scientists in Bulgaria face a bleak future. Read News ▶

Space scope finds scorched super-Earth ▶

Kepler's latest discovery is step closer to a true Earth analogue. Read News ▶

Drought-tolerant maize gets US debut ▶

Seed companies race to tap multibillion-dollar market. Read News ▶

US science academy report calls for 'bipolar' research ▶

Arctic and Antarctic scientists are urged to share data, ideas and infrastructure. Read News ▶

Plans for marine protection highlight science gap ▶

Researchers are scrambling to understand how best to deploy conservation zones. Read News ▶

Neuroscience: Thought experiment ▶

Japanese hospitals are using near-infrared imaging to help diagnose psychiatric disorders. But critics are not sure the technique is ready for the clinic. Read Feature ▶

Conservation biology: The end of the wild ▶

Climate change means that national parks of the future won't look like the parks of the past. So what should they look like? Read Feature ▶

Corruption kills ▶

On the anniversary of Haiti's devastating quake, Nicholas Ambraseys and Roger Bilham calculate that 83% of all deaths from building collapse in earthquakes over the past 30 years occurred in countries that are anomalously corrupt. Read Comment ▶

Bring on the biomarkers ▶

The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste. Read Comment ▶

Oceans: The blue frontier ▶

A collection of essays highlights the pressing challenges of managing global waters, finds Clive Schofield. Read Books and Arts ▶

Books in brief ▶

Read Books and Arts ▶

Neuroscience: Knowing and feeling ▶

Owen Flanagan is unconvinced by Antonio Damasio's argument that 'the self' is needed to explain consciousness. Read Books and Arts ▶

Neuroscience: Mind your head ▶

Josie Glausiusz enjoys a thought-provoking exhibition. Read Books and Arts ▶

Survey data are still vital to science ▶

Jack Gilbert, Ronald O'Dor & Timothy Vogel Read Correspondence ▶

Innovation: lessons from UK policy ▶

Ashley J. Stevens Read Correspondence ▶

Evaluate impact of communication ▶

Eric Jensen Read Correspondence ▶

Hungary works on toxic sludge soil ▶

Poonam Kaushik Bakhshi Read Correspondence ▶

Structure of a nanobody-stabilized active state of the β₂ adrenoceptor ▶

Søren G. F. Rasmussen, Hee-Jung Choi, Juan Jose Fung, Els Pardon, Paola Casarosa et al.

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours ... Read Research ▶

Nanoscale chemical tomography of buried organic–inorganic interfaces in the chiton tooth ▶

Lyle M. Gordon & Derk Joester

Biological organisms possess an unparalleled ability to control the structure an... Read Research ▶

Reliability of flipper-banded penguins as indicators of climate change ▶

Claire Saraux, Céline Le Bohec, Joël M. Durant, Vincent A. Viblanc, Michel Gauthier-Clerc et al.

In 2007, the Intergovernmental Panel on Climate Change highlighted an urgent nee... Read Research ▶

Distributed biological computation with multicellular engineered networks ▶

Sergi Regot, Javier Macia, Núria Conde, Kentaro Furukawa, Jimmy Kjellén et al.

Ongoing efforts within synthetic and systems biology have been directed towards ... Read Research ▶

Robust multicellular computing using genetically encoded NOR gates and chemical ‘wires’ ▶

Alvin Tamsir, Jeffrey J. Tabor & Christopher A. Voigt

Computation underlies the organization of cells into higher-order structures, fo... Read Research ▶

Integrative genomics identifies LMO1 as a neuroblastoma oncogene ▶

Kai Wang, Sharon J. Diskin, Haitao Zhang, Edward F. Attiyeh, Cynthia Winter et al.

Neuroblastoma is a childhood cancer of the sympathetic nervous system that accou... Read Research ▶

A role for mitochondria in NLRP3 inflammasome activation ▶

Rongbin Zhou, Amir S. Yazdi, Philippe Menu & Jürg Tschopp

An inflammatory response initiated by the NLRP3 inflammasome is triggered by a v... Read Research ▶

Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding ▶

Martin P. Stewart, Jonne Helenius, Yusuke Toyoda, Subramanian P. Ramanathan, Daniel J. Muller et al.

During mitosis, adherent animal cells undergo a drastic shape change, from essen... Read Research ▶

c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex ▶

Cristina Aguilera, Kentaro Nakagawa, Rocio Sancho, Atanu Chakraborty, Brian Hendrich et al.

AP-1 (activator protein 1) activity is strongly induced in response to numerous ... Read Research ▶

Structure and function of an irreversible agonist-β₂ adrenoceptor complex ▶

Daniel M. Rosenbaum, Cheng Zhang, Joseph A. Lyons, Ralph Holl, David Aragao et al.

G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins th... Read Research ▶

The structural basis for agonist and partial agonist action on a β₁-adrenergic receptor ▶

Tony Warne, Rouslan Moukhametzianov, Jillian G. Baker, Rony Nehmé, Patricia C. Edwards et al.

β-adrenergic receptors (βARs) are G-protein-coupled receptors (GPCRs... Read Research ▶

H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes ▶

Beth A. Helmink, Anthony T. Tubbs, Yair Dorsett, Jeffrey J. Bednarski, Laura M. Walker et al.

DNA double-strand breaks (DSBs) are generated by the recombination activating ge... Read Research ▶

ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks ▶

Shan Zha, Chunguang Guo, Cristian Boboila, Valentyn Oksenych, Hwei-Ling Cheng et al.

Classical non-homologous DNA end-joining (NHEJ) is a major mammalian DNA double-... Read Research ▶

Reversing pathological neural activity using targeted plasticity ▶

Navzer D. Engineer, Jonathan R. Riley, Jonathan D. Seale, Will A. Vrana, Jai A. Shetake et al.

Brain changes in response to nerve damage or cochlear trauma can generate pathol... Read Research ▶

Identification of two genes causing reinforcement in the Texas wildflower Phlox drummondii  ▶

Robin Hopkins & Mark D. Rausher

Species formation generates biological diversity and occurs when traits evolve t... Read Research ▶

Animal behaviour: The price tag ▶

Rory P. Wilson

Studies of animal populations often use tags to track the fate of individuals an... Read Research ▶

Structural biology: Finding the wet spots ▶

Vincent J. Hilser

The functions of proteins are critically coupled to their interplay with water, ... Read Research ▶

Conservation: The trouble with bumblebees ▶

Mark J. F. Brown

A survey of bumblebees in North America provides unequivocal evidence that four ... Read Research ▶

Synthetic biology: Division of logic labour ▶

Bochong Li & Lingchong You

Cellular compartmentalization is an effective way to build gene circuits capable... Read Research ▶

Cell signalling: Binding the receptor at both ends ▶

Stephen R. Sprang

G-protein-coupled receptors initiate a wide range of signalling pathways in cell... Read Research ▶

Climate change ecology: Butterflies break out earlier ▶

 Read News and Comment ▶

Microbiology: 'Jet lag' weakens malaria parasite ▶

 Read News and Comment ▶

Ecology: The effects of opossum shrimp ▶

 Read News and Comment ▶

Cell biology: Best of two microscopes ▶

 Read News and Comment ▶

Cancer genetics: One catastrophe, many mutations ▶

 Read News and Comment ▶

Neuroimmunology: Immune input for retinal repair ▶

 Read News and Comment ▶

Molecular evolution: The birth of a gene ▶

 Read News and Comment ▶

Think big ▶

The best way to manage national parks in the face of the effects of climate change is not to manage at the park level, but to work with landscapes. A new US initiative shows the way. Read News and Comment ▶

First do no harm ▶

Simple tools to diagnose mental illness should not be offered without sound supporting evidence. Read News and Comment ▶

Bring on the biomarkers ▶

The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste. Read News and Comment ▶

Books in brief ▶

 Read News and Comment ▶

Neuroscience: Knowing and feeling ▶

Owen Flanagan is unconvinced by Antonio Damasio's argument that 'the self' is needed to explain consciousness. Read News and Comment ▶

Neuroscience: Mind your head ▶

Josie Glausiusz enjoys a thought-provoking exhibition. Read News and Comment ▶

Survey data are still vital to science ▶

 Jack Gilbert, Ronald O'Dor & Timothy Vogel Read News and Comment ▶

Turning point: William Ja ▶

William Ja changed his focus from chemistry to biology, and found success. Read Careers ▶

More News & Comment on Biological Sciences ▶

Structure of a nanobody-stabilized active state of the β₂ adrenoceptor ▶

Søren G. F. Rasmussen, Hee-Jung Choi, Juan Jose Fung, Els Pardon, Paola Casarosa et al.

G protein coupled receptors (GPCRs) exhibit a spectrum of functional behaviours ... Read Research ▶

Nanoscale chemical tomography of buried organic–inorganic interfaces in the chiton tooth ▶

Lyle M. Gordon & Derk Joester

Biological organisms possess an unparalleled ability to control the structure an... Read Research ▶

A role for mitochondria in NLRP3 inflammasome activation ▶

Rongbin Zhou, Amir S. Yazdi, Philippe Menu & Jürg Tschopp

An inflammatory response initiated by the NLRP3 inflammasome is triggered by a v... Read Research ▶

Structure and function of an irreversible agonist-β₂ adrenoceptor complex ▶

Daniel M. Rosenbaum, Cheng Zhang, Joseph A. Lyons, Ralph Holl, David Aragao et al.

G-protein-coupled receptors (GPCRs) are eukaryotic integral membrane proteins th... Read Research ▶

The structural basis for agonist and partial agonist action on a β₁-adrenergic receptor ▶

Tony Warne, Rouslan Moukhametzianov, Jillian G. Baker, Rony Nehmé, Patricia C. Edwards et al.

β-adrenergic receptors (βARs) are G-protein-coupled receptors (GPCRs... Read Research ▶

Cell signalling: Binding the receptor at both ends ▶

Stephen R. Sprang

G-protein-coupled receptors initiate a wide range of signalling pathways in cell... Read Research ▶

Hungary works on toxic sludge soil ▶

 Poonam Kaushik Bakhshi Read News and Comment ▶

More News & Comment on Chemical Sciences ▶

A distortion of very-high-redshift galaxy number counts by gravitational lensing ▶

J. Stuart B. Wyithe, Haojing Yan, Rogier A. Windhorst & Shude Mao

The observed number counts of high-redshift galaxy candidates have been used to ... Read Research ▶

Local charge of the ν=5/2 fractional quantum Hall state ▶

Vivek Venkatachalam, Amir Yacoby, Loren Pfeiffer & Ken West

Electrons moving in two dimensions under the influence of strong magnetic fields... Read Research ▶

Two-dimensional electron gas with universal subbands at the surface of SrTiO₃  ▶

A. F. Santander-Syro, O. Copie, T. Kondo, F. Fortuna, S. Pailhès et al.

As silicon is the basis of conventional electronics, so strontium titanate (SrTi... Read Research ▶

Nanoscale chemical tomography of buried organic–inorganic interfaces in the chiton tooth ▶

Lyle M. Gordon & Derk Joester

Biological organisms possess an unparalleled ability to control the structure an... Read Research ▶

Reliability of flipper-banded penguins as indicators of climate change ▶

Claire Saraux, Céline Le Bohec, Joël M. Durant, Vincent A. Viblanc, Michel Gauthier-Clerc et al.

In 2007, the Intergovernmental Panel on Climate Change highlighted an urgent nee... Read Research ▶

Distributed biological computation with multicellular engineered networks ▶

Sergi Regot, Javier Macia, Núria Conde, Kentaro Furukawa, Jimmy Kjellén et al.

Ongoing efforts within synthetic and systems biology have been directed towards ... Read Research ▶

Quantum storage of photonic entanglement in a crystal ▶

Christoph Clausen, Imam Usmani, Félix Bussières, Nicolas Sangouard, Mikael Afzelius et al.

Entanglement is the fundamental characteristic of quantum physics—much e... Read Research ▶

A massive protocluster of galaxies at a redshift of z ≈ 5.3 ▶

Peter L. Capak, Dominik Riechers, Nick Z. Scoville, Chris Carilli, Pierre Cox et al.

Massive clusters of galaxies have been found that date from as early as 3.9 bill... Read Research ▶

Broadband waveguide quantum memory for entangled photons ▶

Erhan Saglamyurek, Neil Sinclair, Jeongwan Jin, Joshua A. Slater, Daniel Oblak et al.

The reversible transfer of quantum states of light into and out of matter consti... Read Research ▶

An actively accreting massive black hole in the dwarf starburst galaxy Henize 2-10 ▶

Amy E. Reines, Gregory R. Sivakoff, Kelsey E. Johnson & Crystal L. Brogan

Supermassive black holes are now thought to lie at the heart of every giant gala... Read Research ▶

Particle physics: Beyond Feynman's diagrams ▶

Neil Turok

Generations of physicists have spent much of their lives using Richard Feynman's... Read Research ▶

Condensed-matter physics: The conducting face of an insulator ▶

Elbio Dagotto

Stacking two oxide insulators together is known to yield a conducting system at ... Read Research ▶

Synthetic biology: Division of logic labour ▶

Bochong Li & Lingchong You

Cellular compartmentalization is an effective way to build gene circuits capable... Read Research ▶

Materials science: Spinning yarns of nanotubes ▶

 Read News and Comment ▶

Materials science: Graphene layers made to order ▶

 Read News and Comment ▶

Books in brief ▶

 Read News and Comment ▶

More News & Comment on Physical Sciences ▶

Contrasting crustal production and rapid mantle transitions beneath back-arc ridges ▶

Robert A. Dunn & Fernando Martinez

The opening of back-arc basins behind subduction zones progresses from initial r... Read Research ▶

Reliability of flipper-banded penguins as indicators of climate change ▶

Claire Saraux, Céline Le Bohec, Joël M. Durant, Vincent A. Viblanc, Michel Gauthier-Clerc et al.

In 2007, the Intergovernmental Panel on Climate Change highlighted an urgent nee... Read Research ▶

Animal behaviour: The price tag ▶

Rory P. Wilson

Studies of animal populations often use tags to track the fate of individuals an... Read Research ▶

Earth science: A back-arc in time ▶

Peter Michael

The Eastern Lau spreading centre in the Pacific Ocean is the subject of especial... Read Research ▶

Corruption kills ▶

On the anniversary of Haiti's devastating quake, Nicholas Ambraseys and Roger Bilham calculate that 83% of all deaths from building collapse in earthquakes over the past 30 years occurred in countries that are anomalously corrupt. Read News and Comment ▶

Oceans: The blue frontier ▶

A collection of essays highlights the pressing challenges of managing global waters, finds Clive Schofield. Read News and Comment ▶

Books in brief ▶

 Read News and Comment ▶

Hungary works on toxic sludge soil ▶

 Poonam Kaushik Bakhshi Read News and Comment ▶

More News & Comment on Earth & Environmental Sciences ▶

Equality: The fight for access ▶

Scientists with disabilities seek ways to level the playing field. Read Careers ▶

Turning point: William Ja ▶

William Ja changed his focus from chemistry to biology, and found success. Read Careers ▶

Different strokes ▶

Scientists in Romania and Bulgaria are having the best and the worst of times. Read News and Comment ▶

Drought-tolerant maize gets US debut ▶

Seed companies race to tap multibillion-dollar market. Read News and Comment ▶

Bring on the biomarkers ▶

The dismal patchwork of fragmented research on disease-associated biomarkers should be replaced by a coordinated 'big science' approach, argues George Poste. Read News and Comment ▶

Survey data are still vital to science ▶

Read News and Comment ▶

Innovation: lessons from UK policy ▶

Read News and Comment ▶

Postdoctoral Fellow

Weill Cornell Medical College, Cornell University New York City

Protein Scientist

Cell Guidance Systems Ltd Cambridge, UK

Senior Group Leader in Immunology

Rheumatology Research Group Parc Cientific de Barcelona

PhD in Genomics of the human nucleolus – implications for cancer and aging

National University of Ireland Galway Ireland National University of Ireland, Galway

Canceromatics II: Multilevel Interpretation of Cancer Genome

28.-30.03.11 Madrid, Spain