Special Issue: Metabolism
Science and its sister journals highlight the central role of metabolism in disparate areas of cell biology, physiology, medicine, and synthetic biology.
| Science Podcast
In this week's show: A bacterium that uses arsenic instead of phosphorus, imaging the skin in vivo, science in Brazil, and more. Listen now. |
Science Talk: Name the 2010 Breakthrough
What would you dub the biggest scientific breakthrough of 2010? We're eager to hear your thoughts and will be sharing our picks with you soon! |
Want to add other e-mail alerts? Change your preferences? Cancel alerts? Log in at http://www.sciencemag.org/cgi/etoc!
In this week's issue:
Editorial
Policy-Making Needs Science
Bruce Alberts
http://www.sciencemag.org/cgi/content/summary/330/6009/1287
Research Summaries
This Week in Science
Editor summaries of this week's papers.
http://www.sciencemag.org/content/vol330/issue6009/twis.dtl
Editors' Choice
Highlights of the recent literature
http://www.sciencemag.org/content/vol330/issue6009/twil.dtl
News of the Week
A Powerful and Perplexing New HIV Prevention Tool
Unlike the many HIV prevention trials that have failed or had positive but barely significant results, the Pre-Exposure Prophylaxis Initiative has showed unequivocally that the treated group had 44% fewer infections after an average of 1.2 years.
http://www.sciencemag.org/cgi/content/summary/330/6009/1298
New HIV Infections Drop, But Treatment Demands Rise
Michel Sidibé, executive director of the Joint United Nations Programme on HIV/AIDS, is wrestling to renew the momentum in the battle against HIV/AIDS and turn the funding situation around in the aftermath of the global economic crisis 2 years ago. Sidibé spoke with Science from New York City, where he was visiting the U.N. headquarters.
http://www.sciencemag.org/cgi/content/summary/330/6009/1301
What Poison? Bacterium Uses Arsenic To Build DNA and Other Molecules
In a paper published online by Science this week, researchers describe GFAJ-1, a bacterial strain that they say can replace the phosphorus in its key biomolecules, including DNA, with the legendary poison arsenic.
http://www.sciencemag.org/cgi/content/summary/330/6009/1302
From Science's Online Daily News Site
ScienceNOW reported this week on a new creature dubbed the "squidworm," a black hole that may hold clues to extra dimensions, a backwardly aging mouse, and a giant eruption that wasn't so giant, among other stories.
http://www.sciencemag.org/cgi/content/summary/330/6009/1303
Panel Explores New Funding Pact With Washington
At an intense meeting last week at the National Academies in Washington, D.C., a blue-ribbon panel asked by Congress to recommend how the country's research universities can bolster the nation's well-being spent a day and a half in public discussion with several dozen leaders in higher education, followed by a day of private deliberations aimed at producing a final report next summer.
http://www.sciencemag.org/cgi/content/summary/330/6009/1304
With Money Tight, White House Panel Offers New Path to Energy Research
In a period of avowed austerity in Washington, D.C., can the government spark a technological revolution in energy without raiding the U.S. Treasury? A new report embraced by the White House says yes.
http://www.sciencemag.org/cgi/content/summary/330/6009/1305-a
From the Science Policy Blog
ScienceInsider reported this week that the Howard Hughes Medical Institute is holding a competition to support the research programs of early-career scientists trained in the United States who have now returned home, among other stories.
http://www.sciencemag.org/cgi/content/summary/330/6009/1305-b
Random Samples
http://www.sciencemag.org/content/vol330/issue6009/r-samples.dtl
News Focus
Brazilian Science: Riding a Gusher
A fast-growing economy and oil discoveries are propelling Brazil's research to new heights. But scientific leaders must overcome a weak education system and a low-impact track record.
http://www.sciencemag.org/cgi/content/summary/330/6009/1306
Tapping a Deep, 'Pre-Salt' Bounty
Three years ago, a drill bit struck immense oil deposits deep off the coast of Brazil. Brazilian President Luiz Inácio Lula da Silva promised to use the oil revenue for education and public health. But Brazil's R&D sector has been first to benefit.
http://www.sciencemag.org/cgi/content/summary/330/6009/1308
Talented But Underfunded: Brazil's Future Scientists
Brazil must overcome deep social divisions in order to achieve its dream of becoming a major player in scientific research. Many say the task must begin with improving public schools, where poorly paid teachers offer rote lessons.
http://www.sciencemag.org/cgi/content/summary/330/6009/1311
Letters
Fishing for Data in the Ross Sea
http://www.sciencemag.org/cgi/content/full/330/6009/1316
Assisted Colonization: Move Ahead with Models
http://www.sciencemag.org/cgi/content/full/330/6009/1317-a
Assisted Colonization: Facilitate Migration First
http://www.sciencemag.org/cgi/content/full/330/6009/1317-b
Assisted Colonization: Protect Managed Forests
http://www.sciencemag.org/cgi/content/full/330/6009/1319-a
Corrections and Clarifications
http://www.sciencemag.org/cgi/content/full/330/6009/1319-b
Books et al.
How Neuromythologies Support Sex Role Stereotypes
Diane F. Halpern
Targeting conclusions that are closer to fiction than science, both Fine and Jordan-Young highlight exaggerations, unreplicated claims, and other silliness from research on neurological differences between the human sexes.
http://www.sciencemag.org/cgi/content/summary/330/6009/1320
Shades of Gray in DNA Drama
Barbara Juncosa
Despite its harsh portrait of Rosalind Franklin, Ziegler's play offers an engaging perspective on her role in the discovery of the structure of DNA.
http://www.sciencemag.org/cgi/content/summary/330/6009/1322-a
Books Received
A listing of books received at Science during the week ended 26 November 2010.
http://www.sciencemag.org/cgi/content/summary/330/6009/1322-b
Policy Forum
Developing Health Workforce Capacity in Africa
F. S. Collins et al.
In Africa, programs to improve health will require major investments in institutions that can train and retain health professionals.
http://www.sciencemag.org/cgi/content/summary/330/6009/1324
Perspectives
Cryptic Links in the Ocean
Andreas Teske
Analysis of the bacterial communities in oxygen-depleted water columns reveals a new strategy how microbes link the nitrogen and sulfur cycles in the ocean.
http://www.sciencemag.org/cgi/content/summary/330/6009/1326
The DNA Damage Road Map
N. Friedman and M. Schuldiner
Comparing maps of gene interactions offers insight into how yeast cells repair DNA damage.
http://www.sciencemag.org/cgi/content/summary/330/6009/1327
Dynamic Metabolons
Birger Lindberg Møller
The assembly and disassembly of enzymes complexes may differentiate plant defense responses to insect attack and fungal infection.
http://www.sciencemag.org/cgi/content/summary/330/6009/1328
Opening the Cellular Poison Cabinet
Seamus J. Martin
The assembly and activation of a mitochondrial channel is triggered by direct interaction with signaling molecules that promote cell death.
http://www.sciencemag.org/cgi/content/summary/330/6009/1330
Dedicated to Memory?
Howard Eichenbaum
Rats with a damaged perirhinal cortex exhibit false memory, raising questions about brain organization.
http://www.sciencemag.org/cgi/content/summary/330/6009/1331
High-Temperature Rubber Made from Carbon Nanotubes
Yury Gogotsi
A mixture of carbon nanotubes creates a material that can recover its shape after deformation over a wide temperature range.
http://www.sciencemag.org/cgi/content/summary/330/6009/1332
Research Articles
How Learning to Read Changes the Cortical Networks for Vision and Language
S. Dehaene et al.
Reading changes the mind.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1359
Reports
Carbon Nanotubes with Temperature-Invariant Viscoelasticity from –196° to 1000°C
M. Xu et al.
A dense carbon-nanotube network shows nearly constant viscoelastic properties over an exceptionally wide temperature range.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1364
Video-Rate Molecular Imaging in Vivo with Stimulated Raman Scattering
B. G. Saar et al.
Raman spectra can be acquired rapidly from samples that would otherwise scatter the usable signal.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1368
The Role of Particle Morphology in Interfacial Energy Transfer in CdSe/CdS Heterostructure Nanocrystals
N. J. Borys et al.
Single-particle spectroscopy suggests that non-uniform geometries favor efficient charge separation for light harvesting.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1371
A Cryptic Sulfur Cycle in Oxygen-Minimum–Zone Waters off the Chilean Coast
D. E. Canfield et al.
Bacterial sulfur reduction and oxidation accompanies nitrogen cycling where oxygen levels at depth are low.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1375
Dynamical Response of the Tropical Pacific Ocean to Solar Forcing During the Early Holocene
T. M. Marchitto et al.
Enhanced solar activity caused the tropical Pacific to cool into a La Niña–like state during the mid-Holocene.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1378
Plasticity of Animal Genome Architecture Unmasked by Rapid Evolution of a Pelagic Tunicate
F. Denoeud et al.
A metazoan genome departs from the organization that appears rigidly established in other animal phyla.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1381
Rewiring of Genetic Networks in Response to DNA Damage
S. Bandyopadhyay et al.
A network comparison of genetic interactions mapped at two conditions reveals genetic responses to DNA damage in yeast
http://www.sciencemag.org/cgi/content/abstract/330/6009/1385
BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program
D. Ren et al.
Proapoptotic proteins act directly on mitochondrial "gatekeeper" proteins to initiate apoptotic events during mouse development.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1390
Arabidopsis Type I Metacaspases Control Cell Death
N. S. Coll et al.
An ancient link between cell death control and innate immune receptor function has been discovered in plants.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1393
An Antagonistic Pair of FT Homologs Mediates the Control of Flowering Time in Sugar Beet
P. A. Pin et al.
A homolog of a flowering time gene has evolved a flowering repression function, affecting the seasonal cold response in beet.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1397
Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM
in the Anterior Cingulate Cortex
X.-Y. Li et al.
Nerve injury increases the activity of an enzyme in the brain and contributes to chronic pain–related cortical sensitization.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1400
Micro-Optical Sectioning Tomography to Obtain a High-Resolution Atlas of the Mouse Brain
A. Li et al.
Acquisition of light microscopic data at 1-micrometer resolution for an entire mouse brain has been developed.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1404
Paradoxical False Memory for Objects After Brain Damage
S. M. McTighe et al.
Impaired recognition may be due to treating novel objects as familiar, rather than treating familiar objects as novel.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1408
Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas
J. W. Harbour et al.
A gene implicated in the control of protein degradation is mutated at high frequency in a metastatic eye cancer.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1410
Direct Exchange of Electrons Within Aggregates of an Evolved Syntrophic Coculture of Anaerobic Bacteria
Z. M. Summers et al.
Direct cell-to-cell electron transfer occurs between two related species of bacteria.
http://www.sciencemag.org/cgi/content/abstract/330/6009/1413
Departments
New Products
A weekly roundup of information on newly offered instrumentation, apparatus, and laboratory materials of potential interest to researchers.
http://www.sciencemag.org/cgi/content/summary/330/6009/1419-a
Science Podcast
http://www.sciencemag.org/cgi/content/summary/330/6009/1419-b
From the AAAS Office of Publishing and Member Services
LIFE SCIENCE TECHNOLOGIES: Understanding Apoptosis
Paul Smaglik
http://www.sciencemag.org/cgi/content/summary/330/6009/1420
Unsubscribe or edit your subscriptions for this service at:
http://www.sciencemag.org/cgi/alerts/main
Written requests to unsubscribe may be sent to:
AAAS / Science, 1200 New York Avenue NW, Washington DC 20005, U.S.A.
