nature alert

The party's over ▶

Caffeinated alcoholic drinks, popular with students, are now being targeted by US regulators. But if government is serious about addressing alcohol abuse, it must confront more powerful foes. Read Editorial ▶

Treated fairly? ▶

Moves to price new pharmaceuticals sensibly shouldn't damage the industry's health. Read Editorial ▶

Citizen scientists ▶

Scientists should speak out on the environmental effects of ventures such as tar-sands mining. Read Editorial ▶

Copenhagen shows we need caution in Cancún ▶

Next week's climate meeting in Mexico should avoid talk of more ambitious targets, says Yvo de Boer. First, we need people to believe in green growth. Read Column ▶

Seven days: 25 November 2010 ▶

The week in science Read Seven Days ▶

Cholera tightens grip on Haiti ▶

Those tackling the epidemic are struggling to keep pace with an escalating crisis. Read News ▶

Korean deaths spark inquiry ▶

Cases highlight the challenge of policing multinational trade in stem-cell treatments. Read News ▶

Nobel document triggers debate ▶

Critics say that explanation of the 2010 award in physics slights other contributions to graphene research. Read News ▶

Drug giants turn their backs on RNA interference ▶

A once much-touted technique faces a difficult transition to the clinic. Read News ▶

Climate talks focus on lesser goals ▶

With nations in gridlock over emissions, UN negotiators are concentrating on side deals to revive an ailing process. Read News ▶

The roots of resistance ▶

Learning how melanoma fights back may yield new therapies. Read News ▶

Microbiology: The new germ theory ▶

What can microbiologists who study human bowels learn from those who study the bowels of Earth? Read Feature ▶

Ancient astronomy: Mechanical inspiration ▶

The ancient Greeks' vision of a geometrical Universe seemed to come out of nowhere. Could their ideas have come from the internal gearing of an ancient mechanism? Read Feature ▶

Tar sands need solid science ▶

As Canada exploits its oil sands ever faster, David Schindler calls for industry-independent environmental monitoring to back up better water-quality regulation. Read Comment ▶

Call in the women ▶

A critical mass of female voices changes the tenor of political and corporate decisions — and should be used to galvanize climate policy, says Susan Buckingham. Read Comment ▶

Conservation: China's national treasure ▶

The panda's plight shows how protection often vies with economic necessity, finds Jane Qiu. Read Books and Arts ▶

History: Catching up with the Sun ▶

Douglas Gough enjoys a wide-ranging tour of the many influences of our nearest star. Read Books and Arts ▶

Books in brief ▶

Read Books and Arts ▶

Sculpture: Terrible wonder ▶

Alfred Keller's fastidious models of insects highlight his skill as an observer and a sculptor, finds Martin Kemp. Read Books and Arts ▶

Innovation: The ideas lab ▶

Jascha Hoffman reads about some creative research environments that led to unexpected discoveries. Read Books and Arts ▶

IPCC yet to assess geoengineering ▶

Ottmar Edenhofer Read Correspondence ▶

An intellectual black hole ▶

Larry Gilman Read Correspondence ▶

Space telescope is worth the effort ▶

Matt Mountain, John Grunsfeld & Heidi Hammel Read Correspondence ▶

Correction ▶

Read Correction ▶

Direct conversion of human fibroblasts to multilineage blood progenitors ▶

Eva Szabo, Shravanti Rampalli, Ruth M. Risueño, Angelique Schnerch, Ryan Mitchell et al.

As is the case for embryo-derived stem cells, application of reprogrammed human ... Read Research ▶

Sugar transporters for intercellular exchange and nutrition of pathogens ▶

Li-Qing Chen, Bi-Huei Hou, Sylvie Lalonde, Hitomi Takanaga, Mara L. Hartung et al.

Sugar efflux transporters are essential for the maintenance of animal blood gluc... Read Research ▶

Structure and control of the actin regulatory WAVE complex ▶

Zhucheng Chen, Dominika Borek, Shae B. Padrick, Timothy S. Gomez, Zoltan Metlagel et al.

Members of the Wiskott–Aldrich syndrome protein (WASP) family control cy... Read Research ▶

Bottom-up effects of plant diversity on multitrophic interactions in a biodiversity experiment ▶

Christoph Scherber, Nico Eisenhauer, Wolfgang W. Weisser, Bernhard Schmid, Winfried Voigt et al.

Biodiversity is rapidly declining, and this may negatively affect ecosystem proc... Read Research ▶

Pericytes regulate the blood–brain barrier ▶

Annika Armulik, Guillem Genové, Maarja Mäe, Maya H. Nisancioglu, Elisabet Wallgard et al.

The blood–brain barrier (BBB) consists of specific physical barriers, en... Read Research ▶

Pericytes are required for blood–brain barrier integrity during embryogenesis ▶

Richard Daneman, Lu Zhou, Amanuel A. Kebede & Ben A. Barres

Vascular endothelial cells in the central nervous system (CNS) form a barrier th... Read Research ▶

Selective activation of p53-mediated tumour suppression in high-grade tumours ▶

Melissa R. Junttila, Anthony N. Karnezis, Daniel Garcia, Francesc Madriles, Roderik M. Kortlever et al.

Non-small cell lung carcinoma (NSCLC) is the leading cause of cancer-related dea... Read Research ▶

Stage-specific sensitivity to p53 restoration during lung cancer progression ▶

David M. Feldser, Kamena K. Kostova, Monte M. Winslow, Sarah E. Taylor, Chris Cashman et al.

Tumorigenesis is a multistep process that results from the sequential accumulati... Read Research ▶

Tension directly stabilizes reconstituted kinetochore-microtubule attachments ▶

Bungo Akiyoshi, Krishna K. Sarangapani, Andrew F. Powers, Christian R. Nelson, Steve L. Reichow et al.

Kinetochores are macromolecular machines that couple chromosomes to dynamic micr... Read Research ▶

Nanoscale architecture of integrin-based cell adhesions ▶

Pakorn Kanchanawong, Gleb Shtengel, Ana M. Pasapera, Ericka B. Ramko, Michael W. Davidson et al.

Cell adhesions to the extracellular matrix (ECM) are necessary for morphogenesis... Read Research ▶

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule ▶

Ching-Chieh Tung, Paolo A. Lobo, Lynn Kimlicka & Filip Van Petegem

Many physiological events require transient increases in cytosolic Ca2+ concentr... Read Research ▶

Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase ▶

Ilya J. Finkelstein, Mari-Liis Visnapuu & Eric C. Greene

In physiological settings, nucleic-acid translocases must act on substrates occu... Read Research ▶

Calcium-dependent phospholipid scrambling by TMEM16F ▶

Jun Suzuki, Masato Umeda, Peter J. Sims & Shigekazu Nagata

In all animal cells, phospholipids are asymmetrically distributed between the ou... Read Research ▶

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor ▶

Paula C. A. da Fonseca, Eric H. Kong, Ziguo Zhang, Anne Schreiber, Mark. A. Williams et al.

The ubiquitylation of cell-cycle regulatory proteins by the large multimeric ana... Read Research ▶

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation ▶

Ramin Nazarian, Hubing Shi, Qi Wang, Xiangju Kong, Richard C. Koya et al.

Activating B-RAF(V600E) (also known as BRAF) kinase mutations occur in ~7%... Read Research ▶

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation ▶

Cory M. Johannessen, Jesse S. Boehm, So Young Kim, Sapana R. Thomas, Leslie Wardwell et al.

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) ar... Read Research ▶

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells ▶

Lucia Ricci-Vitiani, Roberto Pallini, Mauro Biffoni, Matilde Todaro, Gloria Invernici et al.

Glioblastoma is a highly angiogenetic malignancy, the neoformed vessels of which... Read Research ▶

Glioblastoma stem-like cells give rise to tumour endothelium ▶

Rong Wang, Kalyani Chadalavada, Jennifer Wilshire, Urszula Kowalik, Koos E. Hovinga et al.

Glioblastoma (GBM) is among the most aggressive of human cancers. A key feature ... Read Research ▶

Bold claims for optogenetics ▶

Nikos K. Logothetis

Arising from J. H. Lee et al. Nature 465, 788–792 (2010); Lee et al. r...In a recent Letter to Nature, Lee and colleagues combined optogenetic stimulatio... Read Research ▶

Cell biology: Raiding the sweet shop ▶

Nicholas J. Talbot

A type of sugar transporter has been discovered that exports glucose from cells.... Read Research ▶

Palaeoanthropology: Early Homo sapiens in China ▶

Robin Dennell

The timing of the dispersal of our species from Africa is a continuing and livel... Read Research ▶

Cell biology: Import and nuclear size ▶

Orna Cohen-Fix

The size of a cell's nucleus is usually proportional to the size of the cell its... Read Research ▶

Mechanoregulation: Cellular seat belts ▶

Yuta Shimamoto & Tarun M. Kapoor

Accurate cell division depends on proper attachment of chromosomes to the microt... Read Research ▶

Cancer: The blind spot of p53 ▶

Anton Berns

It is hoped that reactivating the tumour-suppressor protein p53 will help to com... Read Research ▶

Genomics: Similar bodies, different genomes ▶

 Read News and Comment ▶

Cancer: Metabolic link to breast cancer ▶

 Read News and Comment ▶

Evolution: Neanderthals matured fast ▶

 Read News and Comment ▶

Structural biology: Dopamine receptor revealed ▶

 Read News and Comment ▶

Developmental biology: Blood-vessel cells turn to bone ▶

 Read News and Comment ▶

Gene therapy: Small RNAs aid cell transplants ▶

 Read News and Comment ▶

Zoology: Fish cocoons block biting bugs ▶

 Read News and Comment ▶

The party's over ▶

Caffeinated alcoholic drinks, popular with students, are now being targeted by US regulators. But if government is serious about addressing alcohol abuse, it must confront more powerful foes. Read News and Comment ▶

Treated fairly? ▶

Moves to price new pharmaceuticals sensibly shouldn't damage the industry's health. Read News and Comment ▶

Conservation: China's national treasure ▶

The panda's plight shows how protection often vies with economic necessity, finds Jane Qiu. Read News and Comment ▶

Books in brief ▶

 Read News and Comment ▶

Sculpture: Terrible wonder ▶

Alfred Keller's fastidious models of insects highlight his skill as an observer and a sculptor, finds Martin Kemp. Read News and Comment ▶

Turning point: Mary Gehring ▶

How to thrive as a plant biologist in a biomedical research environment. Read Careers ▶

More News & Comment on Biological Sciences ▶

Sugar transporters for intercellular exchange and nutrition of pathogens ▶

Li-Qing Chen, Bi-Huei Hou, Sylvie Lalonde, Hitomi Takanaga, Mara L. Hartung et al.

Sugar efflux transporters are essential for the maintenance of animal blood gluc... Read Research ▶

Structure and control of the actin regulatory WAVE complex ▶

Zhucheng Chen, Dominika Borek, Shae B. Padrick, Timothy S. Gomez, Zoltan Metlagel et al.

Members of the Wiskott–Aldrich syndrome protein (WASP) family control cy... Read Research ▶

Growth of graphene from solid carbon sources ▶

Zhengzong Sun, Zheng Yan, Jun Yao, Elvira Beitler, Yu Zhu et al.

Monolayer graphene was first obtained as a transferable material in 2004 and has... Read Research ▶

Tension directly stabilizes reconstituted kinetochore-microtubule attachments ▶

Bungo Akiyoshi, Krishna K. Sarangapani, Andrew F. Powers, Christian R. Nelson, Steve L. Reichow et al.

Kinetochores are macromolecular machines that couple chromosomes to dynamic micr... Read Research ▶

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule ▶

Ching-Chieh Tung, Paolo A. Lobo, Lynn Kimlicka & Filip Van Petegem

Many physiological events require transient increases in cytosolic Ca2+ concentr... Read Research ▶

Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase ▶

Ilya J. Finkelstein, Mari-Liis Visnapuu & Eric C. Greene

In physiological settings, nucleic-acid translocases must act on substrates occu... Read Research ▶

Structures of APC/CCdh1 with substrates identify Cdh1 and Apc10 as the D-box co-receptor ▶

Paula C. A. da Fonseca, Eric H. Kong, Ziguo Zhang, Anne Schreiber, Mark. A. Williams et al.

The ubiquitylation of cell-cycle regulatory proteins by the large multimeric ana... Read Research ▶

Cell biology: Raiding the sweet shop ▶

Nicholas J. Talbot

A type of sugar transporter has been discovered that exports glucose from cells.... Read Research ▶

Nanotechnology: Peptides as biological semiconductors ▶

Charlotte A. E. Hauser & Shuguang Zhang

A simple peptide that assembles into desirable nanoscale structures is a strikin... Read Research ▶

Mechanoregulation: Cellular seat belts ▶

Yuta Shimamoto & Tarun M. Kapoor

Accurate cell division depends on proper attachment of chromosomes to the microt... Read Research ▶

Chemistry: Molecular matchmaking ▶

 Read News and Comment ▶

More News & Comment on Chemical Sciences ▶

A geometric measure of dark energy with pairs of galaxies ▶

Christian Marinoni & Adeline Buzzi

Observations indicate that the expansion of the Universe is accelerating, which ... Read Research ▶

The dynamical mass of a classical Cepheid variable star in an eclipsing binary system ▶

G. Pietrzyński, I. B. Thompson, W. Gieren, D. Graczyk, G. Bono et al.

Stellar pulsation theory provides a means of determining the masses of pulsating... Read Research ▶

Bose–Einstein condensation of photons in an optical microcavity ▶

Jan Klaers, Julian Schmitt, Frank Vewinger & Martin Weitz

Bose–Einstein condensation (BEC)—the macroscopic ground-state ac... Read Research ▶

Growth of graphene from solid carbon sources ▶

Zhengzong Sun, Zheng Yan, Jun Yao, Elvira Beitler, Yu Zhu et al.

Monolayer graphene was first obtained as a transferable material in 2004 and has... Read Research ▶

Snapshots of cooperative atomic motions in the optical suppression of charge density waves ▶

Maximilian Eichberger, Hanjo Schäfer, Marina Krumova, Markus Beyer, Jure Demsar et al.

Macroscopic quantum phenomena such as high-temperature superconductivity, coloss... Read Research ▶

Cosmology: Geometry of the Universe ▶

Alan Heavens

A neat way of measuring the geometry of the Universe offers a new test of the st... Read Research ▶

Nanotechnology: Peptides as biological semiconductors ▶

Charlotte A. E. Hauser & Shuguang Zhang

A simple peptide that assembles into desirable nanoscale structures is a strikin... Read Research ▶

Quantum optics: Particles of light ▶

James Anglin

Bose–Einstein condensation, which demonstrates the wave nature of materi... Read Research ▶

Material science: Stopping ice before it forms ▶

 Read News and Comment ▶

History: Catching up with the Sun ▶

Douglas Gough enjoys a wide-ranging tour of the many influences of our nearest star. Read News and Comment ▶

Books in brief ▶

 Read News and Comment ▶

IPCC yet to assess geoengineering ▶

 Ottmar Edenhofer Read News and Comment ▶

An intellectual black hole ▶

 Larry Gilman Read News and Comment ▶

Space telescope is worth the effort ▶

 Matt Mountain, John Grunsfeld & Heidi Hammel Read News and Comment ▶

Small science yields big growth ▶

Nanomaterials have evolved from innovation to application — and the career possibilities have blossomed. Read Careers ▶

More News & Comment on Physical Sciences ▶

Geology: Hills emerge as glaciers retreat ▶

 Read News and Comment ▶

Citizen scientists ▶

Scientists should speak out on the environmental effects of ventures such as tar-sands mining. Read News and Comment ▶

Tar sands need solid science ▶

As Canada exploits its oil sands ever faster, David Schindler calls for industry-independent environmental monitoring to back up better water-quality regulation. Read News and Comment ▶

Books in brief ▶

 Read News and Comment ▶

IPCC yet to assess geoengineering ▶

 Ottmar Edenhofer Read News and Comment ▶

An intellectual black hole ▶

 Larry Gilman Read News and Comment ▶

Space telescope is worth the effort ▶

 Matt Mountain, John Grunsfeld & Heidi Hammel Read News and Comment ▶

More News & Comment on Earth & Environmental Sciences ▶

Small science yields big growth ▶

Nanomaterials have evolved from innovation to application — and the career possibilities have blossomed. Read Careers ▶

Turning point: Mary Gehring ▶

How to thrive as a plant biologist in a biomedical research environment. Read Careers ▶

Overseas enrolment up ▶

A 30% rise in students from China is behind record highs at US institutions. Read Careers ▶

Changing order ▶

Emerging nations challenging for top research spots. Read Careers ▶

Faculty seek support ▶

Junior staff want more grant-applications help from institutions. Read Careers ▶

Copenhagen shows we need caution in Cancún ▶

Next week's climate meeting in Mexico should avoid talk of more ambitious targets, says Yvo de Boer. First, we need people to believe in green growth. Read News and Comment ▶

Korean deaths spark inquiry ▶

Cases highlight the challenge of policing multinational trade in stem-cell treatments. Read News and Comment ▶

Drug giants turn their backs on RNA interference ▶

A once much-touted technique faces a difficult transition to the clinic. Read News and Comment ▶

Climate talks focus on lesser goals ▶

With nations in gridlock over emissions, UN negotiators are concentrating on side deals to revive an ailing process. Read News and Comment ▶

Tar sands need solid science ▶

As Canada exploits its oil sands ever faster, David Schindler calls for industry-independent environmental monitoring to back up better water-quality regulation. Read News and Comment ▶

IPCC yet to assess geoengineering ▶

Read News and Comment ▶

PhD Position - Transcriptional regulation of neocortical development in the mouse

Ulm University Ulm, Germany

Research Associate

University of Glasgow Glasgow, UK

Postdoctoral Researcher in Algal Proteomics

Colorado State University Fort Collins, CO

Systems Biologist

Sage Bionetworks Seattle, WA

Protein Quality Control in Neurodegenerative Diseases

09.05.11 Paris, France