nature

THIS WEEK

Editorials

There's a time to be critical ▶

An accusation that referees are too demanding and editors too supine demands a response. Authors, editors and referees all have lessons to learn.

Getting personal ▶

Targeted therapies work, but need help to fulfil their potential.

The human epoch ▶

Official recognition for the Anthropocene would focus minds on the challenges to come.

World View

Add coastal vegetation to the climate critical list ▶

Forests are protected, but carbon sinks in mangroves, seagrasses and marshes are ignored. Margareth da Silva Copertino wants Brazil to change that.

Seven Days

Seven days: 13-19 May 2011 ▶

The week in science

NEWS IN FOCUS

Major reform for climate body ▶

Intergovernmental panel aims to become more responsive.

Shuttle's end spells change at NASA ▶

As the shuttle flies its penultimate mission, the US space agency seeks to fill a looming gap in crew transport.

Japan rethinks its energy policy ▶

Renewables come to the fore as universities take the lead on electricity conservation.

'Soap opera' sours cancer chief hunt ▶

Spain's scientists worried by fallout from high-profile spat.

Geneticists bid to build a better bee ▶

Honeybee genome offers clues for fighting diseases.

Battle of Yucca Mountain rages on ▶

Proposed interim storage unlikely to settle US debate.

Features

Energy: America's top climate cop ▶

The United States has abandoned comprehensive greenhouse-gas curbs, but California is pressing ahead. Mary Nichols is leading the fight against emissions.

Stem cells: The growing pains of pluripotency ▶

The field of induced pluripotent stem cells has grown up fast. Now it is entering the difficult stage.

COMMENT

Nuclear winter is a real and present danger ▶

Models show that even a 'small' nuclear war would cause catastrophic climate change. Such findings must inform policy, says Alan Robock.

Research beyond the recession ▶

Nokia, Toyota and Roche explain how they are weathering the financial crash, the technologies they are investing in and their innovation strategies.

Books and Arts

Neuroscience: My brain made me do it ▶

Adam Kepecs urges caution in considering the unconscious mind in the justice system.

Books in brief ▶

Theatre: The chief designer ▶

A clever play shows how engineer Sergei Korolyov drove the Soviet space programme, finds Philip Ball.

Q&A: Cosmic gardener ▶

Charles Jencks designs landscapes and sculptures to convey concepts in astronomy, biology and mathematics — notably at CERN, Europe's particle-physics lab near Geneva, Switzerland, and in his Garden of Cosmic Speculation near Dumfries in Scotland, UK. On the launch of his new book, he discusses green architecture and metaphor.

Correspondence

Guidelines for HIV in court cases Thomas Leitner | PhDs: what's left if science abdicates? Kenneth S. Kosik | PhDs: Israel also trains plenty Thomas Hays | Crop failure signals biodiversity crisis Kelvin S.-H. Peh | China must reduce fertilizer use too Peng Gong, Lu Liang & Qiang Zhang | Data archiving is a good investment Heather A. Piwowar, Todd J. Vision & Michael C. Whitlock | Noisy oil exploration disrupts marine life Michael Stocker | Address education inequality in India Manas Kaushik & Subha Ramani | Fund experiments on atmospheric hazards Stefano Galmarini, Andreas Stohl & Gerhard Wotawa

Obituary

William Nunn Lipscomb Jr (1919–2011) ▶

Chemist who discovered a new kind of bonding.

Correction

Correction ▶

Cardiovascular biology ▶

Molecular mechanisms and clinical applications of angiogenesis ▶

Lessons on the pathogenesis of aneurysm from heritable conditions ▶

Progress and challenges in translating the biology of atherosclerosis ▶

Heart regeneration ▶

RESEARCH

Latest Online

Non-adaptive origins of interactome complexity ▶

Ariel Fernández & Michael Lynch

The boundaries between prokaryotes, unicellular eukaryotes and multicellular euk...

Agonist-bound adenosine A_2A receptor structures reveal common features of GPCR activation ▶

Guillaume Lebon, Tony Warne, Patricia C. Edwards, Kirstie Bennett, Christopher J. Langmead et al.

Adenosine receptors and β-adrenoceptors are G-protein-coupled receptors (G...

Principles of activation and permeation in an anion-selective Cys-loop receptor ▶

Ryan E. Hibbs & Eric Gouaux

Fast inhibitory neurotransmission is essential for nervous system function and i...

Neural crest regulates myogenesis through the transient activation of NOTCH ▶

Anne C. Rios, Olivier Serralbo, David Salgado & Christophe Marcelle

How dynamic signalling and extensive tissue rearrangements interact to generate ...

Control of visual cortical signals by prefrontal dopamine ▶

Behrad Noudoost & Tirin Moore

The prefrontal cortex is thought to modulate sensory signals in posterior cortic...

COP1 is a tumour suppressor that causes degradation of ETS transcription factors ▶

Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen O’Rourke et al.

The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors in the E26 ...

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA ▶

Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su et al.

Mammalian genomes are populated with thousands of transcriptional enhancers that...

Immunogenicity of induced pluripotent stem cells ▶

Tongbiao Zhao, Zhen-Ning Zhang, Zhili Rong & Yang Xu

Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with def...

Articles and Letters

Global quantification of mammalian gene expression control ▶

Björn Schwanhäusser, Dorothea Busse, Na Li, Gunnar Dittmar, Johannes Schuchhardt et al.

Gene expression is a multistep process that involves the transcription, translat...

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity ▶

Kristine Williams, Jesper Christensen, Marianne Terndrup Pedersen, Jens V. Johansen, Paul A. C. Cloos et al.

Enzymes catalysing the methylation of the 5-position of cytosine (mC) have essen...

Eocene lizard from Germany reveals amphisbaenian origins ▶

Johannes Müller, Christy A. Hipsley, Jason J. Head, Nikolay Kardjilov, André Hilger et al.

Amphisbaenia is a speciose clade of fossorial lizards characterized by a snake-l...

Species–area relationships always overestimate extinction rates from habitat loss ▶

Fangliang He & Stephen P. Hubbell

Extinction from habitat loss is the signature conservation problem of the twenty...

Neuropsin cleaves EphB2 in the amygdala to control anxiety ▶

Benjamin K. Attwood, Julie-Myrtille Bourgognon, Satyam Patel, Mariusz Mucha, Emanuele Schiavon et al.

A minority of individuals experiencing traumatic events develop anxiety disorder...

Stem-cell-triggered immunity through CLV3p–FLS2 signalling ▶

Horim Lee, Ok-Kyong Chah & Jen Sheen

Stem cells in the shoot apical meristem (SAM) of plants are the self-renewable r...

A novel protein family mediates Casparian strip formation in the endodermis ▶

Daniele Roppolo, Bert De Rybel, Valérie Dénervaud Tendon, Alexandre Pfister, Julien Alassimone et al.

Polarized epithelia are fundamental to multicellular life. In animal epithelia, ...

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition ▶

Cihangir Duy, Christian Hurtz, Seyedmehdi Shojaee, Leandro Cerchietti, Huimin Geng et al.

Tyrosine kinase inhibitors (TKIs) are widely used to treat patients with leukaem...

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells ▶

Hao Wu, Ana C. D’Alessio, Shinsuke Ito, Kai Xia, Zhibin Wang et al.

Epigenetic modification of the mammalian genome by DNA methylation (5-methylcyto...

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells ▶

William A. Pastor, Utz J. Pape, Yun Huang, Hope R. Henderson, Ryan Lister et al.

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diver...

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation ▶

Gabriella Ficz, Miguel R. Branco, Stefanie Seisenberger, Fátima Santos, Felix Krueger et al.

Methylation at the 5′ position of cytosine in DNA has important roles in...

News & Views

Biodiversity: Species loss revisited ▶

Carsten Rahbek & Robert K. Colwell

Epigenetics: Tet proteins in the limelight ▶

Nathalie Véron & Antoine H. F. M. Peters

Plant biology: Unveiling the Casparian strip ▶

Markus Grebe

Research Highlights

Zoology: Warblers of the underwater world | Microbiology: Starved cells turn on themselves | Animal behaviour: Strike a pose and hide | Drug design: Designer proteins target flu | Immunology: Blocking brain inflammation | Autoimmunity: Taming psoriasis with vitamin D | Neuroscience: A search for depression genes

NEWS & COMMENT

Getting personal | Synthetic genomes: The next step for the synthetic genome | Research beyond the recession | Neuroscience: My brain made me do it | Books in brief | Guidelines for HIV in court cases Thomas Leitner | Crop failure signals biodiversity crisis Kelvin S.-H. Peh

CAREERS

Forensics: The call of the crime lab | Turning point: Jill Venton

More Biological Sciences ▶

RESEARCH

Latest Online

Agonist-bound adenosine A_2A receptor structures reveal common features of GPCR activation ▶

Guillaume Lebon, Tony Warne, Patricia C. Edwards, Kirstie Bennett, Christopher J. Langmead et al.

Adenosine receptors and β-adrenoceptors are G-protein-coupled receptors (G...

Principles of activation and permeation in an anion-selective Cys-loop receptor ▶

Ryan E. Hibbs & Eric Gouaux

Fast inhibitory neurotransmission is essential for nervous system function and i...

COP1 is a tumour suppressor that causes degradation of ETS transcription factors ▶

Alberto C. Vitari, Kevin G. Leong, Kim Newton, Cindy Yee, Karen O’Rourke et al.

The proto-oncogenes ETV1, ETV4 and ETV5 encode transcription factors in the E26 ...

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA ▶

Dong Wang, Ivan Garcia-Bassets, Chris Benner, Wenbo Li, Xue Su et al.

Mammalian genomes are populated with thousands of transcriptional enhancers that...

Articles and Letters

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells ▶

William A. Pastor, Utz J. Pape, Yun Huang, Hope R. Henderson, Ryan Lister et al.

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diver...

News & Views

Epigenetics: Tet proteins in the limelight ▶

Nathalie Véron & Antoine H. F. M. Peters

Research Highlights

Drug design: Designer proteins target flu

NEWS & COMMENT

William Nunn Lipscomb Jr (1919–2011)

CAREERS

Forensics: The call of the crime lab | Turning point: Jill Venton

More Chemical Sciences ▶

RESEARCH

Latest Online

Interannual atmospheric variability forced by the deep equatorial Atlantic Ocean ▶

Peter Brandt, Andreas Funk, Verena Hormann, Marcus Dengler, Richard J. Greatbatch et al.

Climate variability in the tropical Atlantic Ocean is determined by large-scale ...

Articles and Letters

Unbound or distant planetary mass population detected by gravitational microlensing ▶

T. Sumi, K. Kamiya, D. P. Bennett, I. A. Bond, F. Abe et al.

Since 1995, more than 500 exoplanets have been detected using different techniqu...

Observation of the antimatter helium-4 nucleus ▶

H. Agakishiev, M. M. Aggarwal, Z. Ahammed, A. V. Alakhverdyants, I. Alekseev et al.

High-energy nuclear collisions create an energy density similar to that of the U...

Sharply increased mass loss from glaciers and ice caps in the Canadian Arctic Archipelago ▶

Alex S. Gardner, Geir Moholdt, Bert Wouters, Gabriel J. Wolken, David O. Burgess et al.

Mountain glaciers and ice caps are contributing significantly to present rates o...

Melting of the Earth’s inner core ▶

David Gubbins, Binod Sreenivasan, Jon Mound & Sebastian Rost

The Earth’s magnetic field is generated by a dynamo in the liquid iron c...

News & Views

Astronomy: Bound and unbound planets abound ▶

Joachim Wambsganss

Earth science: A deep foundry ▶

Bruce Buffett

Research Highlights

Physics: : Achieving spin control | Materials science: Diamond lighter than a feather

NEWS & COMMENT

Nuclear winter is a real and present danger | Research beyond the recession | Books in brief | Theatre: The chief designer | Q&A: Cosmic gardener

More Physical Sciences ▶

RESEARCH

Latest Online

Interannual atmospheric variability forced by the deep equatorial Atlantic Ocean ▶

Peter Brandt, Andreas Funk, Verena Hormann, Marcus Dengler, Richard J. Greatbatch et al.

Climate variability in the tropical Atlantic Ocean is determined by large-scale ...

Articles and Letters

Unbound or distant planetary mass population detected by gravitational microlensing ▶

T. Sumi, K. Kamiya, D. P. Bennett, I. A. Bond, F. Abe et al.

Since 1995, more than 500 exoplanets have been detected using different techniqu...

Sharply increased mass loss from glaciers and ice caps in the Canadian Arctic Archipelago ▶

Alex S. Gardner, Geir Moholdt, Bert Wouters, Gabriel J. Wolken, David O. Burgess et al.

Mountain glaciers and ice caps are contributing significantly to present rates o...

Melting of the Earth’s inner core ▶

David Gubbins, Binod Sreenivasan, Jon Mound & Sebastian Rost

The Earth’s magnetic field is generated by a dynamo in the liquid iron c...

News & Views

Astronomy: Bound and unbound planets abound ▶

Joachim Wambsganss

Earth science: A deep foundry ▶

Bruce Buffett

Economics: A positive side of disaster ▶

Arun Agrawal

Research Highlights

Seismology: : Awakening a fault line within

NEWS & COMMENT

The human epoch | Nuclear winter is a real and present danger | Books in brief | Theatre: The chief designer | China must reduce fertilizer use too Peng Gong, Lu Liang & Qiang Zhang | Noisy oil exploration disrupts marine life Michael Stocker | Fund experiments on atmospheric hazards Stefano Galmarini, Andreas Stohl & Gerhard Wotawa

More Earth & Environmental Sciences ▶

Synthetic genomes: The next step for the synthetic genome ▶

Biologists have copied an existing genetic code, but haven't yet commercialized it or written their own. What will it take for a tour de force to reach industrial force? 

Forensics: The call of the crime lab ▶

Forensic scientists can work in academia, government and the private sector, but the field is competitive.

Turning point: Jill Venton ▶

An analytical chemist turned neuroscientist probes fruitfly brain function.

Careers related news & comment

There's a time to be critical | Energy: America's top climate cop | Research beyond the recession | PhDs: what's left if science abdicates? Kenneth S. Kosik | PhDs: Israel also trains plenty Thomas Hays | Noisy oil exploration disrupts marine life Michael Stocker | Address education inequality in India Manas Kaushik & Subha Ramani | Fund experiments on atmospheric hazards Stefano Galmarini, Andreas Stohl & Gerhard Wotawa

20 Early Stage Researchers (PhD students) and 4 Experienced Researchers (PostDocs) for ITN CHEBANA - Chemical Bioanalysis

Regensburg University GERMANY

Early stage researcher for ITN TESIS: infants’ embodied and affective responses to gestures

University of Portsmouth Portsmouth, UNITED KINGDOM

Lab-on-a-Chip European Congress

30.06.-01.07.11 Hamburg, Germany