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The science that matters. Every week.

 
     
 
 
 
 
 
   
 
 

xcellence - BEYOND FLUORESCENCE
Whatever fluorescence challenges, the Olympus xcellence system is always the right system. With an amazing array of advanced fluorescence techniques, including TIRFM, FRET, and FRAP, combined with outstanding speed, precision and flexibility as standard, xcellence moves microscopy away from being a tool for "seeing" - to being an instrument for "discovery".

 
 
 
 
 
 

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 News & Comment    Biological Sciences    Chemical Sciences
 
 Physical Sciences    Earth & Environmental Sciences    Careers & Jobs
 
 
 

This week's highlights

 
 

Physical Sciences

More Physical sciences
 
Hot Jupiters from secular planet–planet interactions
 

About a quarter of the known hot Jupiter exoplanets are orbiting in the ‘wrong direction’, or counter to the spin axis of the host star. A new model suggests that the explanation may lie in long-term interactions with a more-distant planet.

 
 
 

Biological Sciences

More Biological sciences
 
Metabolite-enabled eradication of bacterial persisters by aminoglycosides
 

Metabolic stimuli, including glucose and pyruvate, increase the efficacy of aminoglycoside antiobiotics against dormant ‘persister’ bacteria.

 
 
 

Biological Sciences

More Biological sciences
 
Modelling schizophrenia using human induced pluripotent stem cells
 

Fibroblasts from patients with schizophrenia can be reprogrammed as induced pluripotent stem cells and subsequently differentiated into neurons, providing a possible basis for a test-tube model of the disease.

 
 
 
 
 
 
 
 
 
   
 
 

NPG Asia Materials - The latest in materials research from the Asia-Pacific region.

Current content Volume 3 April 2011 | Keep up to date by registering for weekly email alerts
Review: Millimeter-wave photonic wireless links for very high data rate communication
Research highlights: Photonics: Wearable solar cells | Zeolites: Chiral pores make it big | Graphene: How hot is it?

 
 
 
 
 
 
 
 

Podcast & Video

 
 

In this week's podcast,the earliest social mammals, a new type of fungus and how scientists can best showcase themselves online. Plus, the rest of the best from this week's Nature.

 
 
 
 
News & Comment Read daily news coverage top
 
 
 
 
 
 

THIS WEEK

 
 
 
 
 

Editorials

 
     
 
 
 
 
 

Those who can ▶

 
 

An initiative from Scientific American aims to find 1,000 scientists to visit schools, help teachers and boost US education.

 
 
 
 
 
 

Value judgements ▶

 
 

The scientific endeavour needs to deliver public value, not just research papers.

 
 
 
 
 
 

Online image ▶

 
 

The Internet offers ways for researchers to steer public perceptions, for bad and good.

 
 
 
 
 
 

World View

 
     
 
 
 
 
 

Dubious assumptions prime population bomb ▶

 
 

The United Nations says there could be 10 billion people on Earth by the end of the century. Fred Pearce finds problems in its analysis.

 
 
 
 
 
 

Seven Days

 
     
 
 
 
 
 

Seven days: 06-12 May 2011 ▶

 
 

The week in science

 
 
 
 
 

NEWS IN FOCUS

 
 
 
 
 

Troubled probe upholds Einstein ▶

 
 

General relativity vindicated, but was the mission worth it?

 
 
 
 
 
 

Salmonella hits US teaching labs ▶

 
 

Wave of infections triggers investigation into biosafety practices.

 
 
 
 
 
 

Human influence comes of age ▶

 
 

Geologists debate epoch to mark effects of Homo sapiens.

 
 
 
 
 
 

How green is my future? ▶

 
 

UN panel foresees big growth in renewable energy, but policies will dictate just how big.

 
 
 
 
 
 

The collider that cried 'Higgs' ▶

 
 

Data leaks from particle hunters raise questions about scientific trust.

 
 
 
 
 
 

Costs to keep ocean drilling ship in port ▶

 
 

Ten-year programme aims for rebirth in tough climate.

 
 
 
 
 
 

Features

 
     
 
 
 
 
 

Online reputations: Best face forward ▶

 
 

A Nature poll reveals how researchers guard, and sometimes burnish, their online image.

 
 
 
 
 
 

Volcanology: Europe's ticking time bomb ▶

 
 

Vesuvius is one of the most dangerous volcanoes in the world — but scientists and the civil authorities can't agree on how to prepare for a future eruption.

 
 
 
 
 

COMMENT

 
 
 
 
 

WHO needs change ▶

 
 

The World Health Organization needs major reform to regain its leadership as a convener and provider of scientific and technical knowledge, says Barry R. Bloom.

 
 
 
 
 
 

Rebuilding seismology ▶

 
 

Two months on from the earthquake and tsunami that hit their country on 11 March, five Japanese seismologists reflect on what they have learned from it so far.

 
 
 
 
 
 

Books and Arts

 
     
 
 
 
 
 

Climate economics: Corporate greening falls short ▶

 
 

Gail Whiteman is unconvinced by an argument that naked greed and market forces will drive businesses to cut their emissions.

 
 
 
 
 
 

Communication: Popcorn and Petri dishes ▶

 
 

Cinemas are today's scientific lecture halls, finds Kevin Hand in a book probing how research enriches film.

 
 
 
 
 
 

Books in brief ▶

 
 
 
 
 
 

Art: Taking the long view of nature ▶

 
 

A monograph highlights how artist Tania Kovats views geological and evolutionary time, notes Colin Martin.

 
 
 
 
 
 

Art: Pinball wizardry ▶

 
 

A European show reveals new ways of thinking about energy, Daniel Cressey learns.

 
 
 
 
 
 

Correspondence

 
     
 
 
 
 
 

Collaborations span 1,553 kilometres Robert J. W. Tijssen, Ludo Waltman & Nees Jan van Eck | Open up monitoring of deep-sea drilling Henry A. Ruhl & Imants G. Priede | Modernize Ukraine's university system Alexander Gorobets | Tracking China's publication boom Thomas S. Jones & Andrew M. Plume

 
 
 
 
 

Obituary

 
     
 
 
 
 
 

Baruch Blumberg (1925–2011) ▶

 
 

Geneticist whose discovery led to a vaccine for hepatitis B.

 
 
 
 
 
 
 
 
 
 
   
 
 

Graphene: The Road to Applications
May 11-13, 2011 • Cambridge, MA, USA
This meeting will focus on those applications of graphene that are most likely to reach the market within the next 5-10 years or sooner, and strategies to overcome the roadblocks along the way. For more information and to register visit: nature.com/natureconferences/graphene

 
 
 
 
 
 
 
Biological Sciences top
 
 
 
 
 
 

RESEARCH

 
 
 
 
 

Latest Online

 
     
 
 
 
 
 

Structure and function of a membrane component SecDF that enhances protein export ▶

 
 

Tomoya Tsukazaki, Hiroyuki Mori, Yuka Echizen, Ryuichiro Ishitani, Shuya Fukai et al.

 
 

Protein translocation across the bacterial membrane, mediated by the secretory t...

 
 
 
 
 
 

Discovery of novel intermediate forms redefines the fungal tree of life ▶

 
 

Meredith D. M. Jones, Irene Forn, Catarina Gadelha, Martin J. Egan, David Bass et al.

 
 

Fungi are the principal degraders of biomass in terrestrial ecosystems and estab...

 
 
 
 
 
 

Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine ▶

 
 

Scott G. Hansen, Julia C. Ford, Matthew S. Lewis, Abigail B. Ventura, Colette M. Hughes et al.

 
 

The acquired immunodeficiency syndrome (AIDS)-causing lentiviruses human immunod...

 
 
 
 
 
 

Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors ▶

 
 

Pengyu Huang, Zhiying He, Shuyi Ji, Huawang Sun, Dao Xiang et al.

 
 

The generation of functional hepatocytes independent of donor liver organs is of...

 
 
 
 
 
 

Non-apoptotic role of BID in inflammation and innate immunity ▶

 
 

Garabet Yeretssian, Ricardo G. Correa, Karine Doiron, Patrick Fitzgerald, Christopher P. Dillon et al.

 
 

Innate immunity is a fundamental defence response that depends on evolutionarily...

 
 
 
 
 
 

Glutamate induces de novo growth of functional spines in developing cortex ▶

 
 

Hyung-Bae Kwon & Bernardo L. Sabatini

 
 

Mature cortical pyramidal neurons receive excitatory inputs onto small protrusio...

 
 
 
 
 
 

Earliest evidence of mammalian social behaviour in the basal Tertiary of Bolivia ▶

 
 

Sandrine Ladevèze, Christian de Muizon, Robin M. D. Beck, Damien Germain & Ricardo Cespedes-Paz

 
 

The vast majority of Mesozoic and early Cenozoic metatherian mammals (extinct re...

 
 
 
 
 
 

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells ▶

 
 

William A. Pastor, Utz J. Pape, Yun Huang, Hope R. Henderson, Ryan Lister et al.

 
 

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diver...

 
 
 
 
 
 

Articles and Letters

 
     
 
 
 
 
 

Enterotypes of the human gut microbiome ▶

 
 

Manimozhiyan Arumugam, Jeroen Raes, Eric Pelletier, Denis Le Paslier, Takuji Yamada et al.

 
 

Our knowledge of species and functional composition of the human gut microbiome ...

 
 
 
 
 
 

Sequential interactions with Sec23 control the direction of vesicle traffic ▶

 
 

Christopher Lord, Deepali Bhandari, Shekar Menon, Majid Ghassemian, Deborah Nycz et al.

 
 

How the directionality of vesicle traffic is achieved remains an important unans...

 
 
 
 
 
 

Evolution and metabolic significance of the urea cycle in photosynthetic diatoms ▶

 
 

Andrew E. Allen, Christopher L. Dupont, Miroslav Oborník, Aleš Horák, Adriano Nunes-Nesi et al.

 
 

Diatoms dominate the biomass of phytoplankton in nutrient-rich conditions and fo...

 
 
 
 
 
 

Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria ▶

 
 

Chris R. Reisch, Melissa J. Stoudemayer, Vanessa A. Varaljay, I. Jonathan Amster, Mary Ann Moran et al.

 
 

Dimethylsulphoniopropionate (DMSP) accounts for up to 10% of carbon fixed by mar...

 
 
 
 
 
 

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito ▶

 
 

Nikolai Windbichler, Miriam Menichelli, Philippos Aris Papathanos, Summer B. Thyme, Hui Li et al.

 
 

Genetic methods of manipulating or eradicating disease vector populations have l...

 
 
 
 
 
 

Metabolite-enabled eradication of bacterial persisters by aminoglycosides ▶

 
 

Kyle R. Allison, Mark P. Brynildsen & James J. Collins

 
 

Bacterial persistence is a state in which a sub-population of dormant cells, or ...

 
 
 
 
 
 

Modelling schizophrenia using human induced pluripotent stem cells ▶

 
 

Kristen J. Brennand, Anthony Simone, Jessica Jou, Chelsea Gelboin-Burkhart, Ngoc Tran et al.

 
 

Schizophrenia (SCZD) is a debilitating neurological disorder with a world-wide p...

 
 
 
 
 
 

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans ▶

 
 

Mark Lucanic, Jason M. Held, Maithili C. Vantipalli, Ida M. Klang, Jill B. Graham et al.

 
 

Dietary restriction is a robust means of extending adult lifespan and postponing...

 
 
 
 
 
 

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia ▶

 
 

Apostolos Klinakis, Camille Lobry, Omar Abdel-Wahab, Philmo Oh, Hiroshi Haeno et al.

 
 

Notch signalling is a central regulator of differentiation in a variety of organ...

 
 
 
 
 
 

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase ▶

 
 

Virginia Guarani, Gianluca Deflorian, Claudio A. Franco, Marcus Krüger, Li-Kun Phng et al.

 
 

Notch signalling is a key intercellular communication mechanism that is essentia...

 
 
 
 
 
 

Preserving the membrane barrier for small molecules during bacterial protein translocation ▶

 
 

Eunyong Park & Tom A. Rapoport

 
 

Many proteins are translocated through the SecY channel in bacteria and archaea ...

 
 
 
 
 
 

News & Views

 
     
 
 
 
 
 

Cancer: The flipside of Notch ▶

 
 

Demetrios Kalaitzidis & Scott A. Armstrong

 
 
 
 
 
 

Cell signalling: Why fasting worms age slowly ▶

 
 

Luciano De Petrocellis & Vincenzo Di Marzo

 
 
 
 
 
 

Archaeology: The cost of cultivation ▶

 
 

Graeme Barker

 
 
 
 
 
 

Research Highlights

 
     
 
 
 
 
 

Evolution: To make a new species | Genomics: Gene for malarial drug dodging | Organismal biology: Sea urchins 'see' with their feet | Cell biology: : Deeper insight into a single cell | Molecular biology: Protein maker and gene regulator

 
 
 
 

NEWS & COMMENT

 
 
 
 
 

WHO needs change | Books in brief | Art: Taking the long view of nature | Baruch Blumberg (1925–2011)

 
 
 
 
 

CAREERS

 
 
 
 
 

Turning point: John Dabiri | Massachusetts openings

 
 
 
 
 
 

More Biological Sciences ▶

 
 
 
 
 
 
 
 
 
 
   
 
 

Nature Special: Human Microbiota
The human body is colonized by a vast number of microbes, collectively referred to as the human microbiota. The link between these microbes and our health is the focus of a growing number of research initiatives, and new insights are emerging rapidly, some of which we are proud to present in this special collection. Access the special online.

 
 
 
 
 
 
 
Chemical Sciences top
 
 
 
 
 
 

RESEARCH

 
 
 
 
 

Latest Online

 
     
 
 
 
 
 

Structure and function of a membrane component SecDF that enhances protein export ▶

 
 

Tomoya Tsukazaki, Hiroyuki Mori, Yuka Echizen, Ryuichiro Ishitani, Shuya Fukai et al.

 
 

Protein translocation across the bacterial membrane, mediated by the secretory t...

 
 
 
 
 
 

Non-apoptotic role of BID in inflammation and innate immunity ▶

 
 

Garabet Yeretssian, Ricardo G. Correa, Karine Doiron, Patrick Fitzgerald, Christopher P. Dillon et al.

 
 

Innate immunity is a fundamental defence response that depends on evolutionarily...

 
 
 
 
 
 

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells ▶

 
 

William A. Pastor, Utz J. Pape, Yun Huang, Hope R. Henderson, Ryan Lister et al.

 
 

5-hydroxymethylcytosine (5hmC) is a modified base present at low levels in diver...

 
 
 
 
 
 

Articles and Letters

 
     
 
 
 
 
 

Novel pathway for assimilation of dimethylsulphoniopropionate widespread in marine bacteria ▶

 
 

Chris R. Reisch, Melissa J. Stoudemayer, Vanessa A. Varaljay, I. Jonathan Amster, Mary Ann Moran et al.

 
 

Dimethylsulphoniopropionate (DMSP) accounts for up to 10% of carbon fixed by mar...

 
 
 
 
 
 

N-acylethanolamine signalling mediates the effect of diet on lifespan in Caenorhabditis elegans ▶

 
 

Mark Lucanic, Jason M. Held, Maithili C. Vantipalli, Ida M. Klang, Jill B. Graham et al.

 
 

Dietary restriction is a robust means of extending adult lifespan and postponing...

 
 
 
 
 
 

Preserving the membrane barrier for small molecules during bacterial protein translocation ▶

 
 

Eunyong Park & Tom A. Rapoport

 
 

Many proteins are translocated through the SecY channel in bacteria and archaea ...

 
 
 
 
 
 

News & Views

 
     
 
 
 
 
 

Cell signalling: Why fasting worms age slowly ▶

 
 

Luciano De Petrocellis & Vincenzo Di Marzo

 
 
 
 
 

CAREERS

 
 
 
 
 

Postdocs need support

 
 
 
 
 
 

More Chemical Sciences ▶

 
 
 
 
 
 
 
Physical Sciences top
 
 
 
 
 
 

RESEARCH

 
 
 
 
 

Latest Online

 
     
 
 
 
 
 

A graphene-based broadband optical modulator ▶

 
 

Ming Liu, Xiaobo Yin, Erick Ulin-Avila, Baisong Geng, Thomas Zentgraf et al.

 
 

Integrated optical modulators with high modulation speed, small footprint and la...

 
 
 
 
 
 

Articles and Letters

 
     
 
 
 
 
 

Controllability of complex networks ▶

 
 

Yang-Yu Liu, Jean-Jacques Slotine & Albert-László Barabási

 
 

The ultimate proof of our understanding of natural or technological systems is r...

 
 
 
 
 
 

Hot Jupiters from secular planet–planet interactions ▶

 
 

Smadar Naoz, Will M. Farr, Yoram Lithwick, Frederic A. Rasio & Jean Teyssandier

 
 

About 25 per cent of ‘hot Jupiters’ (extrasolar Jovian-mass plan...

 
 
 
 
 
 

A single-atom quantum memory ▶

 
 

Holger P. Specht, Christian Nölleke, Andreas Reiserer, Manuel Uphoff, Eden Figueroa et al.

 
 

The faithful storage of a quantum bit (qubit) of light is essential for long-dis...

 
 
 
 
 
 

Quantum annealing with manufactured spins ▶

 
 

M. W. Johnson, M. H. S. Amin, S. Gildert, T. Lanting, F. Hamze et al.

 
 

Many interesting but practically intractable problems can be reduced to that of ...

 
 
 
 
 
 

News & Views

 
     
 
 
 
 
 

Complex networks: Degrees of control ▶

 
 

Magnus Egerstedt

 
 
 
 
 
 

Astrophysics: Era of the compact disk ▶

 
 

Pieter van Dokkum

 
 
 
 
 
 

Quantum physics: Keep your feet on the ground ▶

 
 

William D. Oliver

 
 
 
 
 
 

Research Highlights

 
     
 
 
 
 
 

Spectroscopy: NMR without the magnet | Photonics: Light switch at the speed of light | Agriculture: Heat hurts crop production | Nanotechnology: Solar cells improve with acid

 
 
 
 

NEWS & COMMENT

 
 
 
 
 

Value judgements | Art: Pinball wizardry

 
 
 
 
 

CAREERS

 
 
 
 
 

Postdocs need support

 
 
 
 
 
 

More Physical Sciences ▶

 
 
 
 
 
 
 
Earth & Environmental Sciences top
 
 
 
 
 
 

RESEARCH

 
 
 
 
 

Latest Online

 
     
 
 
 
 
 

Inferring nonlinear mantle rheology from the shape of the Hawaiian swell ▶

 
 

N. Asaadi, N. M. Ribe & F. Sobouti

 
 

The convective circulation generated within the Earth’s mantle by buoyan...

 
 
 
 
 
 

Articles and Letters

 
     
 
 
 
 
 

Hot Jupiters from secular planet–planet interactions ▶

 
 

Smadar Naoz, Will M. Farr, Yoram Lithwick, Frederic A. Rasio & Jean Teyssandier

 
 

About 25 per cent of ‘hot Jupiters’ (extrasolar Jovian-mass plan...

 
 
 
 
 
 

Spin crossover and iron-rich silicate melt in the Earth’s deep mantle ▶

 
 

Ryuichi Nomura, Haruka Ozawa, Shigehiko Tateno, Kei Hirose, John Hernlund et al.

 
 

A melt has greater volume than a silicate solid of the same composition. But thi...

 
 
 
 
 
 

Research Highlights

 
     
 
 
 
 
 

Atmospheric science: Methane rises from wetlands | Agriculture: Heat hurts crop production

 
 
 
 

NEWS & COMMENT

 
 
 
 
 

Value judgements | Rebuilding seismology | Climate economics: Corporate greening falls short | Books in brief | Art: Taking the long view of nature | Open up monitoring of deep-sea drilling Henry A. Ruhl & Imants G. Priede

 
 
 
 
 

CAREERS

 
 
 
 
 

Geosciences: Earth works

 
 
 
 
 
 

More Earth & Environmental Sciences ▶

 
 
 
 
 
 
 
 
 
 
 
 

Nature Climate Change – Second issue now published

With the second issue of Nature Climate Change now published and the first issue still free to view online, browse the latest content to get a flavour of the areas that this new journal covers. Nature Climate Change accepts submissions through our online system, and welcomes manuscripts from both the physical and social science communities. For further details view the complete Guide to Authors.

 
 
 
 
 
 
 
Careers & Jobs top
 
 
 
 
 
 
 

Geosciences: Earth works ▶

 
 

There's good news for aspiring geoscientists. Job opportunities at all career stages are on the rise.

 
 
 
     
 
 
 

Turning point: John Dabiri ▶

 
 

A biophysicist who linked jellyfish hydrodynamics to blood flow now turns his attention to wind energy.

 
 
 
     
 
 
 

US applications rise ▶

 
 

The number of overseas applications to US graduate schools increased in 2011.

 
 
 
     
 
 
 

Postdocs need support ▶

 
 

A survey says that UK postdocs need more pastoral care and career advice.

 
 
 
     
 
 
 

Massachusetts openings ▶

 
 

A cancer-therapeutics start-up aims to recruit up to 20 researchers.

 
 
 
     
 
 
 

Careers related news & comment

 
     
 
 
 
 
 

Those who can | Online image | How green is my future? | Climate economics: Corporate greening falls short | Collaborations span 1,553 kilometres Robert J. W. Tijssen, Ludo Waltman & Nees Jan van Eck | Open up monitoring of deep-sea drilling Henry A. Ruhl & Imants G. Priede | Modernize Ukraine's university system Alexander Gorobets | Tracking China's publication boom Thomas S. Jones & Andrew M. Plume

 
 
 
 
 
 

naturejobs.com

naturejobs.com Science jobs of the week

 
 
 

PhD Studentships in Integrative Neuroscience

 
 

National University of Ireland Galway Galway, Ireland

 
 
 
 
 

Research Associate (Assistant Professor)

 
 

University of Chicago Department of Organismal Biology and Anatomy Chicago, IL

 
 
 
 
 

MSc in Stem Cells & Regeneration (by distance-learning)

 
 

The University of Bristol Bristol, UK

 
 
 
 
 

Lecturer in Functional Cell Biology

 
 

University of Exeter Exeter, United Kingdom

 
 
 
 

No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. Keep up-to-date with the latest sector trends, vote in our reader poll and sign-up to receive the monthly Naturejobs newsletter.

 
 
 
 
  Nature events featured events  
 
 
 
 

natureevents.com - The premier science events website

natureevents featured events

 
 
 
 

Lab-on-a-Chip European Congress

 
 

30.06.-01.07.11 Hamburg, Germany

 
 
 
 

Nature events is the premier resource for scientists looking for the latest scientific conferences, courses, meetings and symposia. Featured across Nature Publishing Group journals and centrally at natureevents.com it is an essential reference guide to scientific events worldwide.

 
 
 
 
 
 
 

Futures

 
     
 
 
 
 
 

The Universe reef ▶

 
 

Tobias Buckell

 
 

Up, up and away....

 
 
 
 
     
 

 

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